Crystal Structure of Human Liver Δ⁴-3-Ketosteroid 5β-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis

Luigi Di Costanzo, Jason E. Drury, Trevor M. Penning and David W. Christianson

The Journal of Biological Chemistry 283 ( 24 ): 16830 - 16839 , 2008