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Articles by U.B. Ekaluo
Total Records ( 6 ) for U.B. Ekaluo
  E.V. Ikpeme , U.B. Ekaluo , Y.B. Ibiang , O.U. Udensi and P.B. Ekpo
  This study was designed to evaluate the effect of ethanolic stem bark extract of Nauclea latifolia, Cylicodiscus gabunensis and Araliopsis souyauxii; three plants used locally as anti-malarials, on haematology and serum enzyme levels in albino rats. Employing a 3x3 factorial arrangement, thirty six male albino rats were randomly assigned into nine groups of four rats each, treated daily with ethanol extract corresponding to 0, 125 and 225 mg kg-1 b.wt. of the three plants. Treatment was administered orally for two months, after which the animals were sacrificed for estimation of study parameters. All data were subjected to analysis of variance, with conclusions drawn at 5% probability level. Results obtained showed that while N. latifolia and A. souyauxii gave no evidence of potential haemo-toxicity, C. gabunensis at 225 mg kg-1 b.wt. significantly reduced haemoglobin content and packed cell volume of the animals. Although alanine transaminase revealed no significant differences, all plants induced significant elevation in alkaline phosphatase levels at both 125 and 225 mg kg-1 b.wt. Aspartate transaminase was also significantly elevated in all plant groups at 225 mg kg-1 b.wt. Overall, the potential toxic effect of these anti-malarial herbs was observed to be more on serum enzyme levels, than on haematology. In quest for standardized anti-malarial preparations from these herbs, we recommend a dose no more than 225 mg kg-1 b.wt. for N. latifolia and A. souyauxii and 125 mg kg-1 b.wt. for C. gabunensis.
  U.B. Ekaluo , E.V. Ikpeme , Y.B. Ibiang and O.S. Amaechina
  The toxicity of monosodium glutamate has been on the increase due to increased patronage of fast foods; with its attendant effects. There have also been attempts to attenuate these effects. Hence, the attenuating role of vitamin C on sperm toxicity induced by monosodium glutamate was accessed on the weight of testes and epididymes, epididymal count, motility, viability, semen pH and sperm head abnormality in albino rat as a model. The male rats were divided into five groups of six rats each. The rats were administered with MSG and vitamin C treatments for 65 days. Vitamin C attenuated the MSG induced toxicity on weight of testes and epididymes, sperm motility, count and sperm head abnormality. Vitamin C can actually attenuate the effect of MSG induced toxicity in rats as a model.
  U.B. Ekaluo , E.V. Ikpeme , Y.B. Ibiang and F.O. Omordia
  Extracts of Annona spp. have been used for several medicinal purposes such as the management of diabetes and its complications, also as antioxidant and antimutagenic agents. There have been attempts to attenuate toxic effects using medicinal plants. Hence, the mitigating effect of soursop (A. muricata) fruit extract on sperm toxicity induced by caffeine was accessed on the weight of testes and epididymes, epididymal sperm count, motility, viability, semen pH and sperm head abnormality in albino rats as a model. The male rats were divided into five groups of six rats each. The rats were administered with treatments of caffeine and Soursop Fruit Extract (SFE) for 65 days. In conclusion, SFE mitigated the caffeine-induced toxicity on weight of testes and epididymes, sperm motility, sperm count and sperm head abnormality in the mammalian model.
  U.B. Ekaluo , Y.B. Ibiang , E.V. Ikpeme and P.B. Ekpo
  This study was designed to evaluate the anti-mutagenic potential of Myristica fragans (Nutmeg) in male rats. Twenty male wistar rats were randomly distributed into four groups. The treatment groups were administered doses corresponding to 0, 200, 400 and 600 mg kg-1 b.wt. of nutmeg aqueous extract for a period of eight weeks. Data were collected on bone marrow micronucleus index, sperm head abnormality and mutation index. Analysis of variance revealed significant (p<0.05) reductions in sperm head abnormality in the nutmeg treated animals, as compared with the control, in a dose dependent manner. The control had the highest value for sperm head abnormality (6.18±0.55), while 600 mg kg-1 b.wt. group had the lowest value (3.80±0.09). Micronucleus index values in the 600 mg kg-1 b.wt. group (1.40±0.25) was significantly reduced, as compared with the control (3.60±0.51). It was also observed that the mutation indices decreased in a dose dependent manner, from 0.00 in the 0 mg kg-1 b.wt. group to -0.384 in the 600 mg kg-1 b.wt. group. Nutmeg extract showed anti-mutagenic properties, which means the plant contains phyto-antimutagens that could be exploited further in drug development, or as standardized phyto-preparations.
  E.V. Ikpeme , U.B. Ekaluo , M.E. Kooffreh and O. Udensi
  This study was aimed at qualitative evaluation of the ethanol seed, leaf and pulp extracts of C. papaya for bioactive compounds and also to investigate their effect on the haematology in male albino rats. A 3x4 factorial experimental layout using randomized complete design was adopted. Results show that the phytochemicals found in seed, leaf and pulp were almost the same but however, in varying proportions. Present result also revealed that there were significant effects (p<0.05) of the extracts on the heamatology of the treated rats, which was blamed on the varying and different variants of bioactive compounds found in the extracts they were administered with. Suggestively, C. papaya extracts could be used to enhance the production of selected blood parameters, taking issue of dosage into consideration.
  U.B. Ekaluo , P.B. Udoh , E.V. Ikpeme and O. Udensi
  Effect of soybean (Glycine max) on serum level of some sex hormones: testosterone, follicle stimulating hormone (FSH), luteinizing hormone/interstitial cell stimulating hormone (LH/ICSH), estradiol and prolactin in male rats was investigated. Twenty male albino rats of 12 weeks old with similar body weights were assigned to four groups of 5 rats each and treatment with soybean meal at 100, 200 and 300 mg kg-1 body weight, respectively daily for 8 weeks. Blood samples collected through cardiac puncture were assayed for levels of hormones. There were dose-dependent effects of the soybean meal on the serum concentration of the hormones. The treatment significantly reduced the levels of testosterone and FSH in the serum while it significantly increased the levels of estradiol, LH/ICSH and prolactin. The results show that soybean (Glycine max) had strong capability to disrupt hormonal functions. Hence, its indiscriminate use could increase the risk of infertility in males.
 
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