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Articles by Ivan Bubanovic
Total Records ( 2 ) for Ivan Bubanovic
  Ivan Bubanovic
  One of the biggest threats to survival is infection, so that the immune system is under permanent and strong evolutionary pressure to be highly responsive. By tracing the evolution of the invertebrate immune system, it can be seen that it largely followed the “classical” model based on bi-directional “predator-prey” relationships. Similarly, the evolutionary emergence of MHC system and the mechanisms of immune recognition in vertebrates came as a direct result of a microbe-exerted selection pressure. The new possibilities gave rise to new conveniences and brought about certain risks in the new forms, like auto-immunity, allo-immunity and reproductive efficacy. To that effect, the evolutionary emergence of the MHC has enabled a more effective defence from intracellular parasites, such as viruses. However, the whole complex of processing/presenting/recognizing of antigens could be closely related to the auto-immunity as a by-product of the evolution of MHC system and adoptive immunity. On the other hand, tumor development is frequently accompanied by the immune response against “self” and altered antigens expressed by tumor cells, because these antigens are the most prevalent molecules recognized by the immune system. The activation of the auto-immune process in parallel with an effective anti-tumor response could mean the failure of protective control mechanisms of the immune reaction that may be responsible for the prevention of auto-immune diseases. At the same time, the activation of suppressor/modulatory mechanisms possibly accompanied by the activation of anti-tumor auto-immune-like immune response could be a factor of anti-tumor immunity failure in all vertebrates.
  Ivan Bubanovic and Stevo Najman
  Comparative oncology is a branch of comparative pathology that is relatively new biomedical discipline. The need for a comparative research into tumors across different groups of living beings has arisen from a relatively old notion that most of multicellular organisms may develop tumors. This apparently very simple fact indicate the possible nature of tumor growth, which can be associated with the basic features of the cells of multicellular organisms such as the division, development, growth and differentiation of cells and tissues. Regarding this, tumor growth is commonly defined as a fundamental disorder in the regulation of cell division, growth, differentiation and cell socialization. In all vertebrates, neoplasia is a disease in which genetically altered cells escape from the normal cell-cycle regulation and monitoring of the immune system. This results in a persistent, expanding or infiltrating growth without control and the architecture of the normal tissue. Concerning the facts that mechanisms of cell sociability control and anti-tumor immune monitoring might be different in different group of animals, especially, in different classes of vertebrates, development of disciplines such as comparative oncology and comparative tumor immunology can be of great scientific importance.
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