MicroRNA expression profiling in diabetic GK rat model

B Huang, W Qin, B Zhao, Y Shi, C Yao, J Li, H Xiao and Y. Jin

Acta Biochimica et Biophysica Sinica, 2009, 41(6), 472-477. DOI: 10.1093/abbs/gmp035

Abstract

MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleotide microarray to monitor miRNA expression profiles of Goto–Kakizaki (GK) and Wistar rats' skeletal muscle. It was found that seven miRNAs were down-expressed and two miRNAs were over-expressed in the muscle of GK rats. Among them, miR-24 showed the most prominent change. p38 MAPK, which is a direct target of miR-24, also showed expression difference. All the data give a clue that miR-24 might be associated with diabetes through down-regulation of p38 MAPK.

ASCI-ID: 1071-42