miR-20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells

X Fan, Y Liu, J Jiang, Z Ma, H Wu, T Liu, M Liu, X Li and H. Tang

Acta Biochimica et Biophysica Sinica, 2010, 42(5), 318-324. DOI: 10.1093/abbs/gmq026

Abstract

MicroRNAs (miRNAs) are emerging as a class of small regulated RNAs, and the alterations of miRNAs are implicated in the initiation and progression of human cancers. Our study shows that inhibition of miR-20a in OVCAR3 ovarian cancer cell line could suppress, whereas overexpression of miR-20a could enhance cell long-term proliferation and invasion. We also confirmed amyloid precursor protein (APP) as a direct target gene of miR-20a. Furthermore, suppression of APP expression could also promote ovarian cancer cell proliferation and invasion, which is consistent with the results of miR-20a overexpression. Therefore, we concluded that the regulation of APP is an important mechanism for miR-20a to promote proliferation and invasion in ovarian cancer cells.

ASCI-ID: 1071-138