Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus
Z. Y Guo
C. W. Chi
Acta Biochimica et Biophysica Sinica,
2010, 42(7), 502-505. DOI: 10.1093/abbs/gmq042
Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that some exocrine venom peptides are probably evolved from the preexisting endocrine peptides during the evolution of cone snails.