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Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus

X Wu, X Shao, Z. Y Guo and C. W. Chi

Acta Biochimica et Biophysica Sinica, 2010, 42(7), 502-505. DOI: 10.1093/abbs/gmq042


Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that some exocrine venom peptides are probably evolved from the preexisting endocrine peptides during the evolution of cone snails.

ASCI-ID: 1071-154

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