Research Article 
On the Protection of ALP Cardiovascular Toxicity by a Novel Mixed Herbal Medicine; Role of Oxidative Stress and Cellular ATP
Amir Baghaei, Neda Hajimohammadi, Maryam Baeeri, Azadeh Mohammadirad, Shokoufeh Hassani and Mohammad Abdollahi
Asian Journal of Animal and Veterinary Advances, 2014, 9(5), 302-311.
Abstract
Aluminum phosphide (AlP) intoxication is becoming a major concern worldwide due to its high mortality rate (30-100%) besides non-availability of effective antidote till date. The aim of present study was to determine the effect of IMOD™, a novel mixed herbal medicine on energy depletion, oxidative stress and change of electrocardiographic (ECG) parameters in the heart tissue of the rats poisoned by AlP. IMOD™ at doses of 13, 20 and 30 mg kg-1 was administered intraperitoneally 30 min after gavage intragastric administration of AlP (0.25 LD50). Sodium bicarbonate was used as the control. After anesthesia, animals were rapidly connected to PowerLab® device for monitoring of ECG, blood pressure and heart rate for 180 min. At 24 h post treatment, rats were decapitated and hearts removed for evaluation of oxidative stress markers and production of energy. AlP ingestion led to significant heart rate and blood pressure decrement as well as ST variation and shortening of PR interval. Administration of IMOD™ normalized AlP-disturbed cardiovascular parameters. IMOD™ also restored heart energy via re-establishment of cellular ATP pool and elimination of oxidative stress markers. These findings confirm the potential benefits of IMOD™ as an effective treatment for acute AlP poisoning that remain to be trialed clinically.
ASCI-ID: 13-664
Similar Articles
Positive Response of Isolated Rat Pancreatic Islets to IMOD; Hopes for Better Transplant Outcome and Graft Function
Asian Journal of Animal and Veterinary Advances, 2011, 6(10), 1019-1025.
Setarud (IMODTM) as a Multiherbal Drug with Promising Benefits in Animal and Human Studies: A Comprehensive Review of Biochemical and Cellular EvidencesAsian Journal of Animal and Veterinary Advances, 2011, 6(12), 1185-1192.
On the Protective Effects of IMOD and Silymarin Combination in a Rat Model of Acute Hepatic Failure Through Anti Oxidative Stress MechanismsAsian Journal of Animal and Veterinary Advances, 2012, 7(1), 38-45.
Benefit of Lemon Verbena in Healthy Subjects; Targeting Diseases Associated with Oxidative StressAsian Journal of Animal and Veterinary Advances, 2011, 6(9), 953-957.
Positive Response of Isolated Rat Pancreatic Islets to IMOD; Hopes for Better Transplant Outcome and Graft FunctionAsian Journal of Animal and Veterinary Advances, 2011, 6(10), 1019-1025.
Setarud (IMODTM) as a Multiherbal Drug with Promising Benefits in Animal and Human Studies: A Comprehensive Review of Biochemical and Cellular EvidencesAsian Journal of Animal and Veterinary Advances, 2011, 6(12), 1185-1192.
Comparative Improvement in Function of Isolated Rat Langerhans Islets by Various Phosphodiesterase 3, 4 and 5 InhibitorsAsian Journal of Animal and Veterinary Advances, 2011, 6(12), 1233-1240.
Retard of Whey Hydrolysates Supplementation on Swimming Exercise-induced Fatigue in MiceAsian Journal of Animal and Veterinary Advances, 2011, 6(12), 1214-1223.
Bone Oxidative Changes during Early Fracture Healing of Postmenopausal Osteoporosis Rat ModelAsian Journal of Animal and Veterinary Advances, 2011, 6(12), 1193-1203.
On the Protective Effects of IMOD and Silymarin Combination in a Rat Model of Acute Hepatic Failure Through Anti Oxidative Stress MechanismsAsian Journal of Animal and Veterinary Advances, 2012, 7(1), 38-45.
A Comprehensive Review of Biochemical and Molecular Evidences from Animal and Human Studies on the Role of Oxidative Stress in Aging: An Epiphenomenon or the CauseAsian Journal of Animal and Veterinary Advances, 2012, 7(1), 1-19.
On the Benefit of Pure Glycyrrhizic Acid on the Function and Metabolic Activity of Isolated Pancreatic Langerhans Islets in vitroAsian Journal of Animal and Veterinary Advances, 2012, 7(11), 1212-1218.
Short-Term Effect of Deltamethrin Treatment on Oxidative Stress Biomarkers in Anatolian Water BuffaloesAsian Journal of Animal and Veterinary Advances, 2010, 5(4), 266-270.
Multi-organ Protective Effects of Cerium Oxide Nanoparticle/Selenium in Diabetic Rats: Evidence for More Efficiency of Nanocerium in Comparison to Metal Form of CeriumAsian Journal of Animal and Veterinary Advances, 2012, 7(7), 605-612.
Lipotoxicity Observed at the Early Phase of Obesity in Cats Fed on High-fat DietAsian Journal of Animal and Veterinary Advances, 2014, 9(2), 134-143.
Potential Role of Cerium Oxide Nanoparticles for Attenuation of Diabetic Nephropathy by Inhibition of Oxidative DamageAsian Journal of Animal and Veterinary Advances, 2016, 11(4), 226-234.
Dynamics of Malondialdehyde Depending on Cadmium Concentration and their Relation with the Daily Weight Gain on the Chicken HybridAsian Journal of Animal and Veterinary Advances, 2017, 12(1), 38-43.
Effects of Ghrelin on Inflammation and Oxidative Stress Parameters in Sepsis-induced Liver Tissue of RatAsian Journal of Animal and Veterinary Advances, 2017, 12(1), 17-23.
Aquafat-O® as a Growth and Physiological Enhancer Agent for Hybrid Red Tilapia, ♂Oreochromis niloticus (L.)×♀Oreochromis mossambicus (Peters)Asian Journal of Animal and Veterinary Advances, 2018, 13(1), 14-24.
Ganoderma boninense (Ganodermataceae) Aqueous Extract Protects Against Liver and Reproductive Alterations in Parastar-Exposed Male Wistar RatsAsian Journal of Animal and Veterinary Advances, 2022, 17(4), 146-156.
Cited By
An electrocardiographic, molecular and biochemical approach to explore the cardioprotective effect of vasopressin and milrinone against phosphide toxicity in rats
Food and Chemical Toxicology, 2015, 80(), 182. DOI: 10.1016/j.fct.2015.02.022
Thermodynamic characterization of proflavine–DNA binding through microcalorimetric studiesThe Journal of Chemical Thermodynamics, 2015, 87(), 1. DOI: 10.1016/j.jct.2015.03.009
Application of power-spectrum–volume fractal method for detecting hypogene, supergene enrichment, leached and barren zones in Kahang Cu porphyry deposit, Central IranJournal of Geochemical Exploration, 2012, 112(), 131. DOI: 10.1016/j.gexplo.2011.08.002
Molecular and biochemical evidence on the protection of cardiomyocytes from phosphine-induced oxidative stress, mitochondrial dysfunction and apoptosis by acetyl-l-carnitineEnvironmental Toxicology and Pharmacology, 2016, 42(), 30. DOI: 10.1016/j.etap.2015.12.019
Antityphoid properties and toxicity evaluation of Harungana madagascariensis Lam (Hypericaceae) aqueous leaf extractJournal of Ethnopharmacology, 2016, 179(), 137. DOI: 10.1016/j.jep.2015.12.037
Investigation of traditional medicinal floral knowledge of Sarban Hills, Abbottabad, KP, PakistanJournal of Ethnopharmacology, 2016, 179(), 208. DOI: 10.1016/j.jep.2015.12.050
Ethnopharmacological survey on medicinal plants used in snakebite treatments in Western and Sabaragamuwa provinces in Sri LankaJournal of Ethnopharmacology, 2016, 179(), 110. DOI: 10.1016/j.jep.2015.12.041
Socio-technical evolution of Decentralized Energy Systems: A critical review and implications for urban planning and policyRenewable and Sustainable Energy Reviews, 2016, 57(), 1025. DOI: 10.1016/j.rser.2015.12.079
A green ultrasonic-assisted liquid–liquid microextraction based on deep eutectic solvent for the HPLC-UV determination of ferulic, caffeic and cinnamic acid from olive, almond, sesame and cinnamon oilTalanta, 2016, 150(), 577. DOI: 10.1016/j.talanta.2015.12.077
Wheat yield prediction using machine learning and advanced sensing techniquesComputers and Electronics in Agriculture, 2016, 121(), 57. DOI: 10.1016/j.compag.2015.11.018
Cementitious materials and agricultural wastes as natural fine aggregate replacement in conventional mortar and concreteJournal of Building Engineering, 2016, 5(), 119. DOI: 10.1016/j.jobe.2015.11.011
Probing suitable therapeutic nanoparticles for controlled drug delivery and diagnostic reproductive health biomarker developmentMaterials Science and Engineering: C, 2016, 61(), 235. DOI: 10.1016/j.msec.2015.12.044
A novel zinc oxide–zirconium (IV) phosphate nanocomposite as antibacterial material with enhanced ion exchange propertiesColloids and Interface Science Communications, 2015, 7(), 1. DOI: 10.1016/j.colcom.2015.11.003
Techno-economic analysis of excess heat driven post-combustion CCS at an oil refineryInternational Journal of Greenhouse Gas Control, 2016, 45(), 130. DOI: 10.1016/j.ijggc.2015.12.019
Mass balance of nitrogen and potassium in urban groundwater in Central Africa, Yaounde/CameroonScience of The Total Environment, 2016, 547(), 382. DOI: 10.1016/j.scitotenv.2015.12.090
A novel application of Paracoccus pantotrophus for the decolorization of melanoidins from distillery effluent under static conditionsJournal of Environmental Management, 2016, 169(), 78. DOI: 10.1016/j.jenvman.2015.12.016
Cytotoxicity of 91 Kenyan indigenous medicinal plants towards human CCRF-CEM leukemia cellsJournal of Ethnopharmacology, 2016, 179(), 177. DOI: 10.1016/j.jep.2015.12.028
Development of a loop-mediated isothermal amplification assay for rapid and sensitive detection of Sporisorium scitamineum in sugarcaneAnnals of Applied Biology, 2016, (), n/a. DOI: 10.1111/aab.12264
The synergism of the binary and ternary solutions of polyethylene glycol, polyacrylamide and Hydroxyethyl cellulose to methane hydrate kinetic inhibitorJournal of Natural Gas Science and Engineering, 2016, 29(), 15. DOI: 10.1016/j.jngse.2015.12.016
Redistilled Liquid Smoke of Oil-Palm Shells as a Preservative for Beef MeatballsJurnal Teknologi dan Industri Pangan, 2015, 26(1), 1. DOI: 10.6066/jtip.2015.26.1.1
Microscopic studies on postmortem vermiform appendix of the adult males of BangladeshIrish Journal of Medical Science (1971 -), 2016, 185(1), 249. DOI: 10.1007/s11845-015-1287-4
Floodplain evolution in a confluence zone: Paraná and Ivaí rivers, BrazilGeomorphology, 2016, 257(), 1. DOI: 10.1016/j.geomorph.2015.12.017
The validation of an algorithm for the management of paediatric cervical lymphadenopathyInternational Journal of Pediatric Otorhinolaryngology, 2016, 81(), 5. DOI: 10.1016/j.ijporl.2015.11.034
Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agentsJournal of Ethnopharmacology, 2016, 178(), 222. DOI: 10.1016/j.jep.2015.12.016
Antimicrobial activity of Eucalyptus camaldulensis essential oils and their interactions with conventional antimicrobial agents against multi-drug resistant Acinetobacter baumanniiJournal of Ethnopharmacology, 2016, 178(), 125. DOI: 10.1016/j.jep.2015.12.008
Overlapping boundary based multimedia slice transcoding method and its system for medical video and traffic videoMultimedia Tools and Applications, 2016, (), . DOI: 10.1007/s11042-015-3235-8
Active coating for storage of Mozzarella cheese packaged under thermal abuseFood Control, 2016, 64(), 10. DOI: 10.1016/j.foodcont.2015.12.002
Evaluation of drug prescribing practices in private and general hospitals in Makkah, Saudi ArabiaAfrican Journal of Pharmacy and Pharmacology, 2015, 9(39), 966. DOI: 10.5897/AJPP2015.4320
Anti-nociceptive and anti-inflammatory activities of Holoptelea intrigofolia (Roxb.) planch fruit extract on laboratory animalsAfrican Journal of Pharmacy and Pharmacology, 2015, 9(36), 886. DOI: 10.5897/AJPP2015.4352
Camellia sinensis extract inhibits in vitro pancreatic lipase and has preventive effect on obesity in female rat fed a high-fat dietAfrican Journal of Pharmacy and Pharmacology, 2015, 9(37), 919. DOI: 10.5897/AJPP2015.4325
Antibacterial, antifungal, insecticidal and phytotoxic activities of Indigofera gerardiana rootsAfrican Journal of Pharmacy and Pharmacology, 2015, 9(37), 943. DOI: 10.5897/AJPP2013.3992
Larvicidal activity of Dalbergia brasiliensis (Fabaceae - Papilionoideae) on Aedes aegyptiAfrican Journal of Pharmacy and Pharmacology, 2015, 9(35), 881. DOI: 10.5897/AJPP2015.4420
Effect of aqueous extract of Annona muricata seed on atherogenicity in streptozotocin-induced diabetic ratsAfrican Journal of Pharmacy and Pharmacology, 2015, 9(30), 745. DOI: 10.5897/AJPP2015.4389
Comparative study of analgesic and anti-inflammatory effects of Commiphora opobalsamum with diclofenac in rodentsAfrican Journal of Pharmacy and Pharmacology, 2015, 9(32), 806. DOI: 10.5897/AJPP2015.4395
Minimum Inhibitory Concentration of Lactoperoxidase System Against Escherichia coli in Fresh Bovine MilkJurnal Teknologi dan Industri Pangan, 2015, 26(1), 100. DOI: 10.6066/jtip.2015.26.1.100
Ascochyta blight: isolation, characterization, and development of a rapid method to detect inhibitors of the chickpea fungal pathogen Ascochyta rabieiFungal Biology, 2015, (), . DOI: 10.1016/j.funbio.2015.12.002
Removal of fluorescence and ultraviolet absorbance of dissolved organic matter in reclaimed water by solar lightJournal of Environmental Sciences, 2016, (), . DOI: 10.1016/j.jes.2015.08.021
Incorporation of tannic acid in formulations for topical use in wound healing: A technological prospectingAfrican Journal of Pharmacy and Pharmacology, 2015, 9(26), 662. DOI: 10.5897/AJPP2015.4361
Photoprotective, antibacterial activity and determination of phenolic compounds of Neoglaziovia variegata (Bromeliaceae) by high performance liquid chromatography-diode array detector (HPLC-DAD) analysisAfrican Journal of Pharmacy and Pharmacology, 2015, 9(22), 576. DOI: 10.5897/AJPP2015.4315
In vivo cytotoxic effects of methanol extract of Convolvulus arvensis on 7-12-dimethyl benz(a)antheracene (DMBA) induced skin carcinogenesisAfrican Journal of Pharmacy and Pharmacology, 2015, 9(12), 397. DOI: 10.5897/AJPP2014.4165
Potential antimicrobial and antiproliferative activity of the crude extract of the endophytic fungus Rhizoctonia sp. from Annona crassifloraAfrican Journal of Pharmacy and Pharmacology, 2015, 9(10), 327. DOI: 10.5897/AJPP2014.4252
Anti-nutrients composition and mineral analysis of allium cepa (onion) bulbsAfrican Journal of Pharmacy and Pharmacology, 2015, 9(13), 456. DOI: 10.5897/AJPP2015.4300
Muscarinic activity of aqueous leaves extract of Excoecaria grahamii Stapf 1913 on rabbit blood pressure and toad isolated perfused heartAfrican Journal of Pharmacy and Pharmacology, 2015, 9(5), 114. DOI: 10.5897/AJPP2014.4234
Methanolic extracts from roots and cell suspension cultures of Waltheria americana Linn induce GABA release in cerebral slices of mouse brainAfrican Journal of Pharmacy and Pharmacology, 2015, 9(5), 139. DOI: 10.5897/AJPP2014.4115
In vitro evaluation of the antifungal activity of extracts of Baillonella toxisperma (Pierre), a Sapotaceae, on the growth of some human pathogenic yeastsAfrican Journal of Pharmacy and Pharmacology, 2015, 9(9), 299. DOI: 10.5897/AJPP2014.4243
A Review of Swertia chirayita (Gentianaceae) as a Traditional Medicinal PlantFrontiers in Pharmacology, 2016, 6(), . DOI: 10.3389/fphar.2015.00308
Morpho-agronomic variability of three kola trees accessions [Cola nitida (Vent.) Schott et Endl., Cola acuminata (P. Beauv.) Schott et Endl., and Garcinia kola Heckel] from Southern BeninGenetic Resources and Crop Evolution, 2016, (), . DOI: 10.1007/s10722-015-0362-z
Green biosynthesis of silver nanoparticles using Althaea officinalis radix hydroalcoholic extractArtificial Cells, Nanomedicine, and Biotechnology, 2016, 44(1), 209. DOI: 10.3109/21691401.2014.936064
Peak to average power ratio reduction in OFDM system using hybrid techniqueOptik - International Journal for Light and Electron Optics, 2016, 127(6), 3368. DOI: 10.1016/j.ijleo.2015.12.105
Gold nanoparticles as sensors in the colorimetric and fluorescence detection of chemical warfare agentsCoordination Chemistry Reviews, 2016, 311(), 75. DOI: 10.1016/j.ccr.2015.11.009
Synthesis of a functionalized fibrous adsorbent of high uptake capacity: a study on Pb(ii) uptake and simple acidic site model developmentRSC Adv., 2016, 6(7), 5341. DOI: 10.1039/C5RA20497F
Adsorption, separation, and catalytic properties of densified metal-organic frameworksCoordination Chemistry Reviews, 2016, 311(), 38. DOI: 10.1016/j.ccr.2015.12.004
Challenges and opportunities in the phytoremediation of heavy metals contaminated soils: A reviewEcotoxicology and Environmental Safety, 2016, 126(), 111. DOI: 10.1016/j.ecoenv.2015.12.023
Sources identification and pollution evaluation of heavy metals in the surface sediments of Bortala River, Northwest ChinaEcotoxicology and Environmental Safety, 2016, 126(), 94. DOI: 10.1016/j.ecoenv.2015.12.025
Extraction of cellulose from agricultural waste using Montmorillonite K-10/LiOH and its conversion to renewable energy: Biofuel by using Myrothecium gramineumCarbohydrate Polymers, 2016, 141(), 20. DOI: 10.1016/j.carbpol.2015.12.070
Intermediates for synthetic paraffinic kerosene from microalgaeFuel, 2016, 172(), 29. DOI: 10.1016/j.fuel.2016.01.027
Sodium benzoate, a food preservative, affects the functional and activation status of splenocytes at non cytotoxic doseFood and Chemical Toxicology, 2016, 88(), 40. DOI: 10.1016/j.fct.2015.12.016
Chemical composition and nutritional evaluation of the seeds of Acacia tortilis (Forssk.) Hayne ssp. raddianaFood Chemistry, 2016, 200(), 62. DOI: 10.1016/j.foodchem.2016.01.019
Physical, antioxidant and antimicrobial properties of chitosan films containing Eucalyptus globulus essential oilLWT - Food Science and Technology, 2016, 68(), 356. DOI: 10.1016/j.lwt.2015.12.050
Image processing based technique for classification of fish quality after cypermethrine exposureLWT - Food Science and Technology, 2016, 68(), 408. DOI: 10.1016/j.lwt.2015.11.059
Evaluation of highly unsaturated oleogels as shortening replacer in a short dough productLWT - Food Science and Technology, 2016, 68(), 477. DOI: 10.1016/j.lwt.2015.12.063
Numerical investigation of the inertial loss coefficient and the porous media model for the flow through the perforated sieve trayChemical Engineering Research and Design, 2016, 106(), 126. DOI: 10.1016/j.cherd.2015.12.017
On the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicityArchives of Toxicology, 2017, (), . DOI: 10.1007/s00204-017-1998-6
Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of researchArchives of Industrial Hygiene and Toxicology, 2017, 68(4), . DOI: 10.1515/aiht-2017-68-2989
The role of minocycline in alleviating aluminum phosphide-induced cardiac hemodynamic and renal toxicityEnvironmental Toxicology and Pharmacology, 2018, 64(), 26. DOI: 10.1016/j.etap.2018.09.008
Dihydroxyacetone as a definitive treatment for aluminium phosphide poisoning in ratsArchives of Industrial Hygiene and Toxicology, 2018, 69(2), 169. DOI: 10.2478/aiht-2018-69-3106
Mitochondrial biochemical and histopathological defects induced by the herbicide pendimethalin in tilapia fish (Oreochromis niloticus)Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2021, 242(), 108949. DOI: 10.1016/j.cbpc.2020.108949
Antidotal effect of dihydroxyacetone against phosphine poisoning in miceJournal of Biochemical and Molecular Toxicology, 2021, (), . DOI: 10.1002/jbt.22897
Modification of the hemodynamic and molecular features of phosphine, a potent mitochondrial toxicant in the heart, by cannabidiolToxicology Mechanisms and Methods, 2021, (), 1. DOI: 10.1080/15376516.2021.1998851