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Short Communication
Identification of Free Fatty Acid Receptors GPR40/FFAR1 and GPR120/FFAR4 in a Domestic Cat

Makoto Habara, Makoto Tamanuki, Shingo Ishikawa, Hiroshi Takemitsu, Nobuko Mori, Yuki Okada, Nobuhiro Nakao, Koh Kawasumi, Katsumi Ishioka, Toshiro Arai and Ichiro Yamamoto

Asian Journal of Animal and Veterinary Advances, 2015, 10(4), 185-190.

Abstract

G-protein-coupled receptors (GPRs) 40 and 120 are members of the Free Fatty Acid (FFA) receptor group and are termed FFAR1 and FFAR4, respectively. The aim of this study was to clone cat GPR40 and GPR120 cDNAs in several tissues. There was high sequence homology to other mammalian GPR40 and GPR120, with encoding 320 and 361 amino acid residues, respectively. Cat GPR40 encoded extra 21 amino acid residues in the C-terminal cytoplasmic region. Quantitative RT-PCR revealed expression of GPR40 mRNA in the duodenum, liver and pancreas. The GPR120 mRNA was expressed in adipose tissues, cerebral cortex and colon. In conclusion, GPR40 and GPR120 were well conserved and were expressed in cat tissues with different distribution patterns.

ASCI-ID: 13-730

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