Review Article
Regenerative Therapy for Equine Osteoarthritis: A Concise Review

Ashraf M. Abu-Seida

Asian Journal of Animal and Veterinary Advances, 2015, 10(9), 500-508.

Abstract

Osteoarthritis (OA) is a common cause of lameness in equine and a potential cause of wastage of valuable animals. Furthermore, horse is the ideal large animal model for the preclinical study of cell-based therapy in human joints. In contrast to the drug therapy, regenerative therapy promotes the body’s own healing, restoring the structural architecture and biomechanical function of the injured tissue. Therefore, regenerative therapy field in veterinary medicine continues to evolve rapidly both experimentally and clinically. As the field of regenerative therapy continues to advance, equine practitioners need contemporary information regarding the choice of regenerative biologic type and recommendations regarding clinical implementation of regenerative therapies. Meanwhile, clinicians must also be aware of the limitation in the available knowledge regarding regenerative therapy and the impending regulatory laws that may limit its use in clinical joint diseases in equine. Although, preliminary data generated from clinical trials in human patients and experimental studies in equine osteoarthritis are encouraging, preliminary data have been published about very limited clinical application of regenerative therapies in horses suffering from clinical joint disease and the commercialization of these treatments may be premature. Additional studies are needed to determine the optimum conditions for harvest, culture and expansion of these biologics, appropriate dosing, optimal delivery method, short and long term safety. This review describes the three main biologics used for regenerative therapy, namely; stem cells, Platelet Rich Plasma (PRP) and Autologous Conditioned Serum (ACS) and draws together research findings from in vitro and in vivo studies to give an overview of current regenerative therapies for treatment of osteoarthritis in equine.

ASCI-ID: 13-759

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