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Research Article
Evaluation of Therapeutic and High Doses of Florfenicol on Some Hematological Indexes in Goat

Jan Muhammad Shah, Taufique Ahmed Qureshi, Tahmina Sayed, Qurban Ali Shah, Ilahi Bux Kalhoro, Muhammad Asif Arain, Muhammad Saeed, Farman Ali Siyal and Zohaib Ahmed Bhutto

Asian Journal of Animal and Veterinary Advances, 2016, 11(10), 637-642.

Abstract

Objective: The aim of current study was to evaluate the therapeutic and high doses of florfenicol (FFC) on hematological values in goats. Methodology: Goats were intramuscularly induced with therapeutic (20 mg kg –1 b.wt.) and high doses (40 and 60 mg kg –1 b.wt.) of florfenicol for 3 days with 24 h interval. The blood samples were drawn at different timings from 0-120 h after drug administration and were assayed for the selected hematological parameters. Results: The therapeutic dose of FFC produced no effect on erythrocytes, hemoglobin, packed cell volume and leukocytes indices at all timing points, whereas decreased the lymphocyte count (p<0.05) at 24 h. The high dosages of FFC produced significant effect on erythrocytes, hemoglobin, packed cell volume, leukocytes and lymphocyte indices. In comparison with control, erythrocytic count and hemoglobin level (p<0.05) decreased from 48-72 h. Packed cell volume was observed to be reduced (p<0.05 and p<0.01) for 72 h. The leukocytic count (p<0.05) diminished from 24-72 h. The lymphocytic count decreased (p<0.05 and p<0.01) for 96 h. Clinically, local discomfort, reactions and pain at site of injection and some digestion disturbance were also noticed with high doses of florfenicol during experiment. Conclusion: It was concluded that both the therapeutic and high doses of florfenicol significantly affects the lymphocytes. The high doses of FFC produced anemic and immunosuppressive effects of drug.

ASCI-ID: 13-877

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