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Research Article
Biochemical Investigation of the Effect of Garlic (Allium sativum) on 7,12-dimethylbenz[α]anthracene (DMBA) Induced Mammary Cancer in Female Albino Rats

Moayad Khataibeh, Mahmoud Abu- Samak and Naheed Banu

Asian Journal of Biochemistry, 2006, 1(3), 251-256.

Abstract

The study was designed to investigate the pre and post chemoprotection of garlic on 7, 12-dimethylbenz[α]anthrance (DMBA) induced mammary cancer in female albino rats. Animals (hundred rats) where equally divided into five groups, (twenty rats each). Group I: each rat received 1 mL of 0.1% saline daily for twenty days. Group II: received 1 mL of 0.1% saline given orally once a day for twenty days prior to DMBA infusion (30 mg kg -1) and these rats served as controls (cancer control) for group III. Group III : were pre treated with garlic prior to DMBA infusion. Group IV: received 1 mL of 0.1% saline given orally once a day for twenty days after DMBA infusion and these rats served as cancer control for group V. Group V: Post treated with garlic after DMBA infusion. Biochemical measurement were carried out on liver tissues and serum of experimental animals. Circulating levels of lactate dehydrogenase (LDH), Glutamate Oxaloacetate Transaminase (GOT) and Glutamate Pyrovate Transaminase (GPT) were elevated, while the activities of glutathione-s-transferase (GST) and superoxide dismutase (SOD) and the levels of reduced glutathione (GSH) were reduced in liver tissues in DMBA infused rats as compared to normal. Garlic treatment altered the above mentioned biochemical parameters towards normal values. Present findings indicate that garlic got both pre and post effect on DMBA infused rats, where post treatment is more effective.

ASCI-ID: 16-141

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