Research Article 
TAME-Esterase and Oxidative Stress Contribute to Dysmetabolic Syndrome in Dyslipidaemia
A.H. Subratty, L.H. Semfa and M.D. Manraj
Asian Journal of Biochemistry, 2007, 2(5), 323-329.
Abstract
In this study, the level of oxidative stress and TAME-esterase activity in dyslipidaemic patients were studied. Fasting levels of total peroxides, triglycerides, total cholesterol, HDL-cholesterol, fasting and 2 h post load glucose were determined using commercially available kits among 110 individuals (mean age 47.5±8.5 years) subdivided into 3 groups namely: Optimal LDL (LDL<3.4 mmol L-1), Borderline LDL (3.4 = LDL = 4.2 mmol L-1) and High LDL (LDL>4.2 mmol L-1). TAME-esterase activity was assessed using a simple colorimetric micromethod. Data was analysed using Epi-Info statistical software. Analysis of data showed no association between TAME-esterase activity, total peroxides and dyslipidaemia. TAME-esterase activity was higher in patients with abnormal glucose metabolism as compared to normoglycaemic subjects (p<0.05). It was concluded that TAME-esterase and hence the kinin-kallikrein system may play an important role in insulin resistance and endothelial dysfunction.
ASCI-ID: 16-99
Similar Articles
Modulation of UVB-induced Oxidative Stress by Ursolic Acid in Human Blood Lymphocytes
Asian Journal of Biochemistry, 2008, 3(1), 11-18.
Lipid Peroxidation and Total Antioxidant Capacity in Patients with Chronic Renal FailureAsian Journal of Biochemistry, 2008, 3(5), 315-319.
Serum Paraoxonase Activity and Protein Thiols in Chronic Renal Failure PatientsAsian Journal of Biochemistry, 2007, 2(4), 274-278.
Effect of Organophosphorus on Biochemical Parameters on Agricultural Workers of Mango OrchardsAsian Journal of Biochemistry, 2012, 7(1), 37-45.
Dietary Polyphenols and Human HealthAsian Journal of Biochemistry, 2010, 5(3), 154-162.
Impact of Plasmodium berghei and Chloroquine on Haematological and Antioxidants Indices in MiceAsian Journal of Biochemistry, 2009, 4(1), 30-35.
L-Arginine Ameliorates Arylesterase/Paraoxonase Activity of Paraoxonase-1 in Hypercholesterolemic RatsAsian Journal of Biochemistry, 2011, 6(3), 263-272.
Synergistic Effects of Glutathione and Vitamin E on ROS Mediated Ethanol Toxicity in Isolated Rat HepatocytesAsian Journal of Biochemistry, 2011, 6(4), 347-356.
Oxidative Stress In Anti Thyroperoxidase Antibody Positive Hypothyroid PatientsAsian Journal of Biochemistry, 2012, 7(1), 54-58.
Camel Milk Regulates Gene Expression and Activities of Hepatic Antioxidant Enzymes in Rats Intoxicated with Carbon TetrachlorideAsian Journal of Biochemistry, 2014, 9(1), 30-40.
Hepatocyte Oxidative Stress Indicators of Carbon Tetrachloride Induced Hyperlipidemic Rats (Rattus norvegicus) Treated with Allium sativa ExtractAsian Journal of Biochemistry, 2014, 9(2), 86-97.
Evaluation of Antioxidant Activity of Aqueous Extracts of Palm Fruits (Elaeis guineensis)Asian Journal of Biochemistry, 2017, 12(2), 49-58.
Vitamin C Protects Against Monosodium Glutamate-induced Alterations in Oxidative Markers and ATPases Activities in Rat’s BrainAsian Journal of Biochemistry, 2020, 15(1), 12-20.
Cited By
L-Arginine Ameliorates Arylesterase/Paraoxonase Activity of Paraoxonase-1 in Hypercholesterolemic Rats
Asian Journal of Biochemistry, 2011, 6(3), 263. DOI: 10.3923/ajb.2011.263.272