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Research Article
Antiproliferative, Antioxidant and Apoptosis Effects of Zingiber officinale and 6-Gingerol on HepG2 Cells

Harliansyah, Noor Azian Murad, Wan Zurinah Wan Ngah and Yasmin Anum Mohd Yusof

Asian Journal of Biochemistry, 2007, 2(6), 421-426.

Abstract

The present study was designed to compare the antioxidant, antiproliferative and apoptosis effects of ethanolic extract of ginger (Zingiber officinale) with its phenolic component (6)-Gingerol on human hepatoma cell line (HepG2). We found that cytotoxic and antiproliferative effect of ginger extract and (6)-Gingerol could be associated with induction of apoptosis. Both ginger extract and (6)-Gingerol also showed remarkable antioxidant activities in comparison with ascorbic acid and N-acetyl-L-cysteine.

ASCI-ID: 16-106

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