Biochemical, Hematological and Histopathological Effects of Duranta repens Stems on Rats

Research Article
Biochemical, Hematological and Histopathological Effects of Duranta repens Stems on Rats

F. Nikkon, S. Hasan, M.H. Rahman, M.A. Hoque, A. Mosaddik and M.E. Haque

Asian Journal of Biochemistry, 2008, 3(6), 366-372. DOI:

Abstract

Two triterpenes, β-Amyrin and 12-Oleanene 3β, 21β-diol, were isolated as a mixture from the chloroform soluble fraction of an ethanolic extract of Duranta repens stem. The structures of these two compounds were confirmed by IR, ¹H and ¹³C-NMR spectral data. In acute toxicity test, the chloroform soluble fraction showed toxic effect on rats but compound 1 (mixture of β-Amyrin and 12-Oleanene 3β, 21β-diol) had no toxic effect on rat at 2 mg/kg/day b.wt. Biochemical and hematological profiles of rat`s blood of chloroform soluble fraction were found statistically significant. In histopathological experiment, some degenerative changes on cellular structure of liver, heart and kidney except lungs were found in chloroform soluble fraction treated rats.

ASCI-ID: 16-158

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