Search. Read. Cite.

Easy to search. Easy to read. Easy to cite with credible sources.

Research Article
Preparation and Characterization of Spherical Agglomerates of Piroxicam by Neutralization Method

M. Dixit, P.K. Kulkarni, R.P. Selvam, A.G. Kini and H.G. Shivakumar

American Journal of Drug Discovery and Development, 2011, 1(3), 188-199.


Piroxicam, an anti-inflammatory drug, exhibits poor water solubility and flow properties. The aim of the present study was to develop piroxicam spherical agglomerate and was prepared by neutralization method. Crystallization medium used for spherical agglomerates of piroxicam consisted of 1 N sodium hydroxide; 0.07M HCl, chloroform (bridging liquid) in the ratio of 25:67:8 mL, respectively. Spherical agglomerates were characterized by differential scanning calorimetry, Infrared spectroscopy, X-ray diffractometry and scanning electron microscopy. Micromeritic and mechanical property and dissolution behavior studies were carried out. Process variables such as amount of bridging liquid, stirring time and duration of stirring were optimized. Dissolution profile of the spherical agglomerates was compared with pure sample and recrystallized sample. The samples were stored in stability chamber to investigate their physical stability. Spherical agglomerates exhibited decreased crystallinity and improved micromeritic properties then pure piroxicam. The dissolution of the spherical agglomerates was improved compared with pure sample and recrystallized sample. Dissolution of spherical agglomerates showed higher %release i.e., 63.32% in 60 min compare to other pure piroxicam i.e. 38.17%. In stability test, the release profile of the spherical aggolomeration was almost unchanged as compared with the freshly prepared spherical agglomeration stored at 20°C and 45% relative humidity for 90 days. Hence this technique can be used for formulation of tablets of piroxicam by direct compression with directly compressible tablet excipients.

ASCI-ID: 2817-23

Cited References Fulltext

Cited By

Particle engineering/different film approaches for earlier absorption of meloxicam

Drug Delivery, 2014, (), 1. DOI: 10.3109/10717544.2014.982262

Do green roofs help urban biodiversity conservation?

Journal of Applied Ecology, 2014, 51(6), 1643. DOI: 10.1111/1365-2664.12333

Correlation between Structural Properties and <i><i>In Vivo</i></i> Biocompatibility of Alumina/Zirconia Bioceramics

Key Engineering Materials, 2011, 493-494(), 1. DOI: 10.4028/