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Research Article
Development, in vitro Characterization and Stability Study for Matrix Tablets Containing Chlorpheniramine Maleate Prepared by Direct Compression

Mohamed Haider

American Journal of Drug Discovery and Development, 2015, 5(1), 1-12.


The objectives of this study were to prepare matrix tablets of Chlorpheniramine Maleate (CPM) using a series of hydrophilic and hydrophobic polymers and determine the effect of the type and concentration of the polymer on the physical properties, in vitro drug release and stability of the matrix tablets. The CPM matrix tablets containing 10% w/w and 25% w/w of hydrophilic polymers (hypromellose and Carbopol 934) and hydrophobic polymers (Eudragit S100 and Compritol®) were prepared by direct compression technique. The flow properties of the powder mixtures as well as the physical properties and accelerated stability of the prepared tablets were determined. The CPM release profiles were investigated in vitro using commercially available Pheniram® IR tablets as a control group. The results showed that the type and polymer concentration did not have a significant effect on the flow properties of the powder mixture, the physical properties of the prepared tablets and their short-term stability. In vitro release data showed that matrix tablets containing 25% hypromellose exhibited a superior ability to control the release of CPM associated with complete release and minimum dose dumping, when compared to other formulae. Besides illustrating the effect of polymer type and concentration on the in vitro release of CPM from different matrix tablets, the study showed that hypromellose in concentration of 25% w/w could be a potential candidate to be used in formulating CPM matrix tablets.

ASCI-ID: 2817-107

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