Two Novel Coding SNPs of SREBP1c Gene are Associated with Body Weight and Average Daily Gain in Bovine

Research Article
Two Novel Coding SNPs of SREBP1c Gene are Associated with Body Weight and Average Daily Gain in Bovine

Yongzhen Huang, Enping Zhang, Jing Wang, Yongtao Huai, Xianyong Lan, Liang Ma, Zhuanjian Li, Gang Ren, Fuying Chen, Chuzhao Lei, Juqiang Wang and Hong Chen

Animal Biotechnology, 2010, 21(3), 170-178. DOI: 10.1080/10495391003768813


It is known that the SREBP1c gene is an important gene responsible for adipogenesis and regulation of the expression of genes controlling fatty acid biosynthesis. Its expression levels increase in parallel with obesity. Therefore, the present study focused on screening the genetic variation within bovine SREBP1c gene and analyzing its effect on growth traits in 1035 individuals belonging to four Chinese cattle breeds (QC, NY, JX, CH) using PCR-SSCP, DNA sequencing, and forced PCR-RFLP methods. The results revealed two novel mutations: NC_007317: g. 10781 C > A (457aa), 10914 G > A (502aa). Association analysis with growth traits in the Nangyang breed indicated that: The SNPs in the bovine SREBP1c gene had significant effects on body weight and average daily gain at birth, 6 and 12 months old (P < 0.05 or P < 0.01). Therefore, these results suggest that the SREBP1c gene is a strong candidate gene that affects growth traits in cattle.

ASCI-ID: 259-73

View Fulltext

Similar Articles

A New Tandem Repeat in Bovine Fibrinogen Aα Gene

Animal Biotechnology, 2008, 19(2), 122-126. DOI: 10.1080/10495390801929122

Genomic Organization and Promoter Analysis of the Bovine Adam12 Gene

Animal Biotechnology, 2008, 19(3), 178-189. DOI: 10.1080/10495390802212445

Genomic Location of the Bovine Growth Hormone Secretagogue Receptor (GHSR) Gene and Investigation of Genetic Polymorphism

Animal Biotechnology, 2009, 20(1), 28-33. DOI: 10.1080/10495390802602926

Decreased Expression of Matrix Metalloproteinase-9 and Increased Expression of Tissue Inhibitors of Matrix Metalloproteinase-1 in Paratuberculosis-Infected Cattle in the ELISA-Negative Subclinical Stage

Animal Biotechnology, 2011, 22(1), 44-49. DOI: 10.1080/10495398.2010.536096

Associations of a HinfI PCR-RFLP of POU1F1 Gene with Growth Traits in Qinchuan Cattle

Animal Biotechnology, 2009, 20(2), 71-74. DOI: 10.1080/10495390802640462

SNiPORK - A Microarray of SNPs in Candidate Genes Potentially Associated with Pork Yield and Quality - Development and Validation in Commercial Breeds

Animal Biotechnology, 2008, 19(1), 43-69. DOI: 10.1080/10495390701880946

Porcine Lung Surfactant Protein B Gene (SFTPB): cDNA Sequencing, Chromosomal Location, and Expression Studies

Animal Biotechnology, 2008, 19(3), 127-137. DOI: 10.1080/10495390801977584

Molecular Characterization and SNP Development for the Porcine Il6 and Il10 Genes

Animal Biotechnology, 2008, 19(3), 159-165. DOI: 10.1080/10495390802088621

Generation and Analysis of ESTs from the Grass Carp, Ctenopharyngodon idellus

Animal Biotechnology, 2010, 21(4), 217-225. DOI: 10.1080/10495398.2010.505843

High Concordance of Bovine Single Nucleotide Polymorphism Genotypes Generated Using Two Independent Genotyping Strategies

Animal Biotechnology, 2010, 21(4), 257-262. DOI: 10.1080/10495398.2010.509680

Single Nucleotide Polymorphisms Alter the Promoter Activity of Bovine MIF

Animal Biotechnology, 2011, 22(3), 143-150. DOI: 10.1080/10495398.2011.580219