Research Article
Preliminary Central Nervous System Effects of the Aqueous Seed Extract of Mucuna pruriens in Mice

R.A. Magaji, M.I.A. Saleh, M.G. Magaji and I. Buhari

Current Research in Neuroscience, 2014, 4(1), 6-9.


The seeds of Mucuna pruriens commonly called Velvet or Mucuna beans have extensively been used in Brazilian and Indian traditional Ayurvedic medicine for many ailments. Exploratory behaviors are affected by drugs based on the types of neurotransmitter they interact with in the brain. Diazepam-induced sleep test in four groups of 6 mice treated with intraperitoneal distilled water (10 mL kg-1), 600, 300 and 150 mg kg-1; hole board test for exploratory behavior in 5 groups of mice treated with intraperitoneal distilled water (10 mL kg-1), diazepam (1.5 mg kg-1), 600, 300 and 150 mg kg-1 of Mucuna pruriens aqueous seed extract respectively were carried out. The studies showed that Mucuna pruriens significantly and dose-dependently prolonged the duration of diazepam-induced sleep which suggests that it possess sleep inducing property. The ability of the extract to significantly reduce the number of head dips in the hole-board test corroborates the CNS depressant potential of the plant extract. It is concluded that Mucuna pruriens may be a remedy in some CNS disorders.

ASCI-ID: 70-52

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