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Research Article
In vivo Antioxidant Potential of Momordica charantia Against Cyclophosphamide Induced Hepatic Damage in Rats

Subramanian Senthilkumar, Narayanasamy Nithya, Venkatesan Ganesan and Kalichamy Chandrakumar

International Journal of Biological Chemistry, 2012, 6(3), 89-96.

Abstract

Cyclophosphamide (CP) is one among the important anti-cancer drug that could cause hepatotoxicity due to its toxic metabolites. In the present study, in vivo antioxidant efficacy of Momordica charantia against CP induced liver injury in Wistar rats was evaluated. Hepatic damage in rats was induced by injecting CP i.p. (total of 200 mg kg-1 b.wt.) for 2 days. Protective effect of aqueous extract of Momordica charantia (MCE) was evaluated by assessing enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase) and lipid peroxidation in liver and non-enzymic antioxidants (glutathione, vitamin C and vitamin E) in serum. Administration of MCE (300 mg kg-1 b.wt.) orally for 12 days restored the activities of enzymic antioxidants in liver. Non-enzymic antioxidants were restored to normal level with a concomitant normalized level of lipid peroxidation that could be achieved due to the secondary metabolites, vitamins and minerals content of Momordica charantia. Results of the present study evidenced that supplementation of MCE protected hepatic tissues from oxidative damage induced by CP, due to its protective and antioxidant effects.

ASCI-ID: 34-126

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