Search. Read. Cite.

Easy to search. Easy to read. Easy to cite with credible sources.

Research Article
Feeding Almonds and Pecans Reduced Development of Azoxymethane Induced Precancerous Lesions

A.A. Miller, M. Verghese, J. Boateng, L. Shackelford and L.T. Walker

International Journal of Cancer Research, 2010, 6(4), 234-242.

Abstract

The aim of the study was to test the chemopreventive potential of almonds and pecans on (AOM) induced aberrant crypt foci (ACF). Following a 1 week period of acclimatization, 30 Fisher 344 male rats were randomly divided into 5 groups. One group was fed AIN93G (growth) diet as Control(C) and the other groups were fed almonds (A) and pecans (P) at 5% (5 g/100 g level) and 10% (10 g/100 g level). At 7 and 8 weeks of age rats received subcutaneous injections of Azoxymethane (AOM) at 16 mg kg-1 body weight and were killed by CO2 asphyxiation at 17 weeks of age. Selected enzyme activities such as, glutathione-s-transferase (GST), catalase (CAT) and superoxide dismutase (SOD) were determined. ACF incidence in rats fed Pecans and Almonds at 5 and 10% dose levels were significantly (p<0.05) lower than rats fed control. ACF was reduced by 46-61% in the treatment groups compared to the control. GST and CAT activities (μmol g-1) in rats fed Pecan and Almonds at 5 and 10% dose levels were significantly higher (p<0.05) compared to control fed rats and ranged from 22.03 to 26.44 and 2.38 to 2.98, respectively. We also noted a significant increase in SOD activity (μmol g-1) in rats fed the treatment diets compared to those fed control. Present data indicate that feeding almonds and pecans significantly (p<0.05) reduced incidence of AOM induced ACF which are precancerous lesions.

ASCI-ID: 36-145

Cited References Fulltext

Related Articles


Effects of Processed Peaches (Prunus persica) in Reducing Azoxymethane (AOM) Induced Aberrant Crypt Foci (ACF) in Fisher 344 Male Rats

International Journal of Cancer Research, 2012, 8(1), 1-14.

Inhibitory Effect of Lentils, Green Split and Yellow Peas (Sprouted and Non-sprouted) on Azoxymethane-induced Aberrant Crypt Foci in Fisher 344 Male Rats

International Journal of Cancer Research, 2014, 10(1), 27-36.

Modifying Effects of Pistachio Nuts on Antioxidant Enzymes in Azoxymethane (AOM)-induced Formation of Aberrant Crypt Foci

International Journal of Cancer Research, 2016, 12(3-4), 140-151.

Effects of Processed Peaches (Prunus persica) in Reducing Azoxymethane (AOM) Induced Aberrant Crypt Foci (ACF) in Fisher 344 Male Rats

International Journal of Cancer Research, 2012, 8(1), 1-14.