Anti-Angiogenic Effectiveness of the Pomegranate Against Benzo(a)Pyrene Induced Lung Carcinoma in Mice

Research Article
Anti-Angiogenic Effectiveness of the Pomegranate Against Benzo(a)Pyrene Induced Lung Carcinoma in Mice

International Journal of Cancer Research, 2015, 11(4), 164-174.

Abstract

Pomegranate, a constituent of flavonoids, ellagitannins and ellagic acid is exposed to exert compelling anti-carcinogenic effects. In the present study, we examined the anti-angiogenic and anti-tumorigenic potential of pomegranate juice on benzo(a)pyrene-induced mice lung carcinoma by analyzing the SOD and CAT anti-oxidants, MDA for oxidative stress and the marker of angiogenesis (CD34). Oral administration of pomegranate (10% w/v) to Swiss albino mice suppressed the development of lung carcinoma by disappointment MDA, histopathological lesions and the Micro-Vessels Density (MVD). The significant correlation (p<0.05) was present in an improvements the SOD and CAT anti-oxidants. The results obtained from the present study show that pomegranate inhibits the development of mice lung carcinogenesis through its ability to induce apoptosis and disappointment the formation of new vessels (angiogenesis). Our present findings were that the protective benefits of pomegranate juice may be due in part to its potent anti-oxidant properties and ability to reduce oxidative stress, histopathological injuries by suppressing the formation of reactive oxygen species and protecting the anti-oxidant mechanism and inhibition of MVD. So, this study suggested that the pomegranate is anti-angiogenic effectiveness in the benzo(a)pyrene induced lung carcinoma in mice.

ASCI-ID: 36-277

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