Research Article
In vivo Antioxidant Potentials of Rosa Damascene Petal Extract from Guilan, Iran, Comparable to α-tocopherol

Sanaz Shahriari, Narguess Yasa, Azadeh Mohammadirad, Reza Khorasani and Mohammad Abdollahi

International Journal of Pharmacology, 2007, 3(2), 187-190.

Abstract

Rosa damascena Mill, (Rosaceae) is a widely cultivated ornamental plant. Several therapeutic effects including calmative, antianxiety, laxative and antispasmodic have been described for the flower of R. damascena. The petals of R. damascena are specially used as cardiotonic by the people of Guilan province. In this study antioxidant potential of R. damascena petals were determined by FRAP test and its ability to inhibit lipid peroxidation was determined by TBARS test in rat. In vivo examination was performed by oral administration of ethanol extract of R. damascena petals at doses of 50, 75, 100 and 200 mg/kg/day for 10 days which compared to vitamin E (10 mg/kg/day) and control groups. In vivo evaluation of antioxidant effects of R. damascene with these two methods showed that the extract of R. damascena has a high ability to inhibit lipid peroxidation and has a high antioxidant power with all doses comparing to control (p<0.001). The highest activity was observed with the dose of 200 mg/kg/day. This preliminary study indicates the interesting anti oxidative stress activity of R. damascena, which is comparable to the known antioxidant compound, alpha-tocopherol. R. damascena can be considered as a medicinal source for the treatment and prevention of many free radicals related diseases.

ASCI-ID: 23-328

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International Journal of Pharmacology, 2015, 11(6), 611-617.

Effect of Hyperbaric Oxygenation in Total Antioxidant System, Nitric Oxide and 3 Nitrotyrosine Levels in a Rat Model of Acute Myocardial Infarct in the Absence of Reperfusion

International Journal of Pharmacology, 2015, 11(7), 834-839.

Berberine Analogue Y53 has Improved Antioxidant and Anti-Inflammatory Activities in Diabetic C57BL/6J Mice with Liver Steatosis

International Journal of Pharmacology, 2016, 12(1), 11-18.

Inhibitory Effects of Thyroid Hormones on Mitochondrial Oxidative Stress: A Systematic Review

International Journal of Pharmacology, 2016, 12(3), 249-261.

Antidiabetic and Oxidative Stress Ameliorative Potential of Ethanolic Extract of Pedicularis longiflora Rudolph

International Journal of Pharmacology, 2016, 12(3), 177-187.

Role of Anti-apoptotic Activity of Antioxidants in Conferring Protection Against Prostate Cancer

International Journal of Pharmacology, 2016, 12(4), 304-316.

A Traditional Chinese Medicine Shaoyao Ruangan Heji Ameliorates Carbon Tetrachloride-induced Liver Injury Through Multiple Stress and Toxicity Pathways

International Journal of Pharmacology, 2016, 12(4), 317-328.

Pyridoxine and Zanamivir Alter Levels of Dopamine in Brain of Rats with Induced Hyperglycemia by Inhibition of Oxidative Stress

International Journal of Pharmacology, 2016, 12(3), 161-168.

Effect of Aflatoxin B1 on Histopathology and Oxidative Stress Biomarkers in Testis of Rats with Special References to Gene Expression of Antioxidant Enzymes

International Journal of Pharmacology, 2016, 12(4), 408-414.

Potential Ameliorative Effects of Selenium and Chromium Supplementation Against Toxicity and Oxidative Stress in Streptozotocin Diabetic Rats

International Journal of Pharmacology, 2016, 12(5), 483-495.

Diosmin Protects Against Cyclophosphamide-induced Liver Injury Through Attenuation of Oxidative Stress, Inflammation and Apoptosis

International Journal of Pharmacology, 2016, 12(6), 644-654.

Cinnamaldehyde Mitigates Carbon Tetrachloride-induced Acute Liver Injury in Rats Through Inhibition of Toll-like Receptor 4 Signaling Pathway

International Journal of Pharmacology, 2016, 12(8), 851-862.

Protective Effect of Vitazinc on Chlorsan Induced Oxidative Stress, Genotoxicity and Histopathological Changes in Testicular Tissues of Male Rats

International Journal of Pharmacology, 2017, 13(1), 22-32.

Green Tea Protects Against Perinatal Nicotine-induced Histological, Biochemical and Hematological Alterations in Mice Offspring

International Journal of Pharmacology, 2017, 13(2), 109-121.

Protective Effect of Baicalein on oxLDL-induced Oxidative Stress and Inflammation Injury in Endothelial Cell

International Journal of Pharmacology, 2017, 13(3), 280-285.

Hepatoprotective Effect of Rutin Against Oxidative Stress of Isoniazid in Albino Rats

International Journal of Pharmacology, 2017, 13(6), 516-528.

Oral Intake of Aged Garlic Extract (AGE) Ameliorates Oxidative Stress and Other Streptozotocin-induced Diabetic Complications in Rats

International Journal of Pharmacology, 2017, 13(6), 593-602.

Lipoic Acid and Coenzyme Q10 Protect Against Lead-induced Toxicity in Rats with Metabolic Syndrome

International Journal of Pharmacology, 2016, 12(3), 146-153.

Consumption of ADD-X and Repeatedly Heated Palm Oil on the Blood Pressure and Oxidative Stress Markers in Ovarectmized Rats

International Journal of Pharmacology, 2016, 12(5), 514-522.

Ameliorating Effect of Vitamin C Against Potassium Dichromate Induced Oxidative Stress and Inflammatory Response in Rats

International Journal of Pharmacology, 2017, 13(8), 990-999.

Date Extract Prevent Hypogonadism In Rat Suffering From Liver Damage Induced By Carbon Tetrachloride

International Journal of Pharmacology, 2017, 13(8), 934-945.

Ameliorative Effect of Rutin Against Isoniazid-induced Alterations in Certain Hematological and Biochemical Parameters of Albino Rats

International Journal of Pharmacology, 2018, 14(1), 39-51.

Assessment of the Ameliorative Effect of Ruzu Herbal Bitters on the Biochemical and Antioxidant Abnormalities Induced by High Fat Diet in Wistar Rats

International Journal of Pharmacology, 2018, 14(3), 329-341.

Prophylactic Effect of Diacerein against Cisplatin-Induced Nephrotoxicity in Rats

International Journal of Pharmacology, 2018, 14(3), 384-390.

Protective Effect of Naringenin Against Isoniazid-induced Adverse Reactions in Rats

International Journal of Pharmacology, 2018, 14(5), 667-680.

Antidiabetic and Immunoprophylactic Effects of Camel Milk Filtrate and Bitter Gourd (Momordica charantia) Juice Against Alloxan-induced Oxidative Stress and Diabetes in Rats

International Journal of Pharmacology, 2018, 14(3), 397-406.

Neuroprotective Effects of Melissa officinalis on Oxygen and Glucose Deficiency Induced Damage in Rat’s Brain Cortex Slices

International Journal of Pharmacology, 2018, 14(6), 781-786.

Nephroprotective Effect of Camel Milk and Spirulina platensis in Gentamicin-Induced Nephrotoxicity in Rats

International Journal of Pharmacology, 2018, 14(4), 559-565.

Tadalafil Transdermal Delivery with Alpha-lipoic Acid Self Nanoemulsion for Treatment of Erectile Dysfunction by Diabetes Mellitus

International Journal of Pharmacology, 2018, 14(7), 945-951.

Protective Effects of Quercetin on Selenium-Induced Cataracts via Modulation of Heat Shock Protein 70 Expression

International Journal of Pharmacology, 2018, 14(7), 913-921.

Antioxidant Effect of Carnosine on Aluminum Oxide Nanoparticles (Al2O3-NPs)-induced Hepatotoxicity and Testicular Structure Alterations in Male Rats

International Journal of Pharmacology, 2018, 14(5), 740-750.

Effect of Rutin on Cisplatin-induced Small Intestine (Jejunum) Damage in Rats

International Journal of Pharmacology, 2018, 14(8), 1136-1144.

Effectiveness of Moringa oleifera L. Leaves Extract Against Methotrexate-induced Acute Hepatotoxicity in Male Rats

International Journal of Pharmacology, 2018, 14(7), 1029-1037.

Effectiveness of Osthole on Uric Acid Crystal-induced Acute Gouty Arthritis Through the Inhibition of NLRP3 Inflammasome

International Journal of Pharmacology, 2018, 14(8), 1169-1178.

Anti-diabetic Potential of Cordia dichotoma Pulp and Peel (Functional Fiber) in Type II Diabetic Rats

International Journal of Pharmacology, 2019, 15(1), 102-109.

Ameliorative and Synergistic Effect of Red Raspberry and Lycopene Against Hepatotoxicity Induced by Acrylamide in Male Mice

International Journal of Pharmacology, 2019, 15(2), 166-176.

Potential Antioxidant, Anti-Inflammatory and Gastroprotective Effect of Grape Seed Extract in Indomethacin-induced Gastric Ulcer in Rats

International Journal of Pharmacology, 2019, 15(2), 209-218.

Counteractive Role of White Pepper Extracts for Oxidative Stress and Hepatotoxicity Induced by Aflatoxin B1 in Rats

International Journal of Pharmacology, 2019, 15(2), 177-188.

Histopathological Effect of Aspartame on Liver and Kidney of Mice

International Journal of Pharmacology, 2019, 15(3), 336-342.

Aqueous Green Tea Extract and Prediction of Fibrosis in Lipopolysaccharide Intoxicated Rats

International Journal of Pharmacology, 2019, 15(3), 403-417.

Protective Activity of Taurine and Molecular Fibrogenesis in Iron Overloaded Hepatic Tissues

International Journal of Pharmacology, 2019, 15(3), 418-427.

Inhibitory Effect of Grape Seed Polyphenol Extract and Vitamin C on Melanogenesis in Cultured B16-F1 Melanoma Cells

International Journal of Pharmacology, 2019, 15(5), 533-541.

Reverse of β-Amyloid Induced Apoptosis in PC12 Cells by Nattokinase: Role of SIRT1-ROCK1 Pathway

International Journal of Pharmacology, 2019, 15(5), 593-603.

Protective and Antioxidant Role of Selenium Nanoparticles and Vitamin C Against Acrylamide Induced Hepatotoxicity in Male Mice

International Journal of Pharmacology, 2019, 15(6), 664-674.

Evaluation of Antioxidative Effect of Green Tea Catechins Against Isoniazid-induced Biochemical Alterations in Rats

International Journal of Pharmacology, 2019, 15(7), 777-789.

Barbaloin Ameliorates the Memory in Isoflurane Induced Neuronal Injury by Regulating the BDNF/Bcl-2/PI3K Signaling Pathway

International Journal of Pharmacology, 2019, 15(7), 801-808.

Effect of Datura stramonium on Cyclophosphamide-induced Oxidative Stress in Albino Rats: Study on Kidney Markers

International Journal of Pharmacology, 2019, 15(8), 926-932.

Protective Effect of Celastrol on Gentamicin-induced Nephrotoxicity in Mice

International Journal of Pharmacology, 2020, 16(2), 126-135.

Camel Urine Prevents Cisplatin-induced Nephrotoxicity in Rats by Attenuating Oxidative Stress and Apoptosis

International Journal of Pharmacology, 2020, 16(3), 257-266.

Prevention of Metabolic, Redox and Lipid Biosynthesis Alterations by Visnagin in High Cholesterol-Fed Rats

International Journal of Pharmacology, 2020, 16(5), 398-406.

Effect of Resveratrol on Neurotrophic Factors and Depression-Like Behavior in a Rat Model of Male Hypogonadism

International Journal of Pharmacology, 2021, 17(1), 38-47.

Protective Effect of Nicotiana plumbaginifolia Linn against CCl4 Induced Oxidative Stress in Gallus gallusdomesticus

International Journal of Pharmacology, 2021, 17(3), 130-137.

Valproate Ameliorates Diethylnitrosamine/Phenobarbital- Induced Hepatic Cancer via the Role of TNF-α and TGF-β1

International Journal of Pharmacology, 2021, 17(4), 156-168.

Molecular and Histological Study of Low Molecular Weight Heparin’s Effect Against Cerebral Ischemic Injury

International Journal of Pharmacology, 2021, 17(4), 190-199.

Chlorogenic Acid Improves Cognitive Deficits in Diabetic Rats

International Journal of Pharmacology, 2021, 17(6), 370-379.

Alpha-Pinene Induces Apoptosis through Oxidative Stress and PI3K/AKT/NF-κB Signalling Pathway in MDA-MB-231 Human Breast Cancer Cells

International Journal of Pharmacology, 2021, 17(6), 391-399.

Triphala Suppresses Ovarian Cancer Cell Proliferation through Induction of Apoptosis and ROS in vitro

International Journal of Pharmacology, 2021, 17(7), 491-498.

Astilbin Prevents Neuroinflammation and Mitigates Cognitive Deficits in Lipopolysaccharides Induced Peripheral Infection

International Journal of Pharmacology, 2022, 18(1), 60-69.

Arctigenin Alleviates Oxidative Stress in Cerebral Ischemia/ Reperfusion Injury Rats by Keap1-Nrf2 Pathway

International Journal of Pharmacology, 2021, 17(7), 464-473.

Dipsacus asperoides Extract Improves Physiological Behaviour and Controls Oxidative Stress Produced by a Rat Model of Osteoarthritis

International Journal of Pharmacology, 2022, 18(4), 598-610.

Perioperative Effects of Hydromorphone in Gynecological Laparoscopic Surgery under General Anesthesia

International Journal of Pharmacology, 2022, 18(3), 534-542.

Asiatic acid Improves Physical Fatigue through Regulating Inflammatory Reaction, Oxidative Stress and Energy Metabolism in Mice

International Journal of Pharmacology, 2022, 18(4), 783-793.

Beneficial Effects of Tofacitinib in Long-Standing Diabetes-Induced Cognitive Impairment in Rats through BDNF-TNF-α-Nrf2 Signalling Pathway

International Journal of Pharmacology, 2022, 18(5), 856-863.

Neuroprotective Effects of Different Lavandula stoechas L. Extracts Against Hydrogen Peroxide Toxicity in vitro

International Journal of Pharmacology, 2022, 18(5), 883-896.

Inhibitory Effect of Methotrexate (MTX) Used in Human Cancer Treatment on Paraoxonase-1 (PON1)

International Journal of Pharmacology, 2022, 18(5), 942-946.

Gastrodiae Rhizoma Improve Cognitive Functions and Regulate Keap1/Nrf2-ARE Signal Pathway in APP/PS1 Transgenic Mice

International Journal of Pharmacology, 2022, 18(6), 1101-1115.

Earthworm Extract Exhibits Therapeutic Effect Against Epinephrine-Induced Myocardial Infarction in Rats

International Journal of Pharmacology, 2022, 18(6), 1126-1136.

Significance of LncRNA NEAT1 Alterations During Treatment of Nonalcoholic Fatty Liver Disease and its Association with Gut Microbiota

International Journal of Pharmacology, 2022, 18(6), 1287-1295.

Influence of Nervonic Acid on Parkinson’s Disease Model Cells through Ras/MEK/ERK Axis

International Journal of Pharmacology, 2022, 18(6), 1309-1321.

Is Benidipine Effective in Preventing Gastric Ischemia/ Reperfusion Injury?

International Journal of Pharmacology, 2022, 18(6), 1271-1277.

Effect of Thymoquinone on Diclofenac-Induced Liver Injury

International Journal of Pharmacology, 2022, 18(6), 1331-1339.

Asiatic Acid Ameliorates Cognitive Impairment in Diabetic Rats

International Journal of Pharmacology, 2022, 18(7), 1500-1508.

Inhibitory Effect of Some Plant Extracts on Pancreatic Lipase

International Journal of Pharmacology, 2010, 6(1), 18-24.

Inhibitory Activity of Some Plant Methanol Extracts on 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase

International Journal of Pharmacology, 2010, 6(5), 705-711.

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