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Research Article
Antigenotoxic Effect of Genistein and Gingerol on Genotoxicity Induced by Norethandrolone and Oxandrolone in Cultured Human Lymphocytes

Tanveer Beg, Yasir Hasan Siddique, Gulshan Ara, Jyoti Gupta and Mohammad Afzal

International Journal of Pharmacology, 2008, 4(3), 177-183.

Abstract

Norethandrolone and Oxandrolone were studied for their genotoxic effect on human lymphocyte chromosomes using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) as parameters and subsequently Genistein and Gingerol were used as antigenotoxic agents to ameliorate the genotoxicity induced by the steroids. This experiment was aimed at finding the dosage at which these two steroids are genotoxic enough to cause chromosome damage. They were studied at 5, 10, 20, 30 and 40 μM, respectively and were found to be significantly genotoxic at 30 and 40 μM. Genistein and Gingerol proved to be equally effective in reducing genotoxic damage at appropriate doses. The results suggest a strong genotoxic effect of both steroids in vitro in human lymphocytes and also a significant antigenotoxic action of Genistein and Gingerol against steroid induced genotoxic damage.

ASCI-ID: 23-2

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