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Research Article
Protective Effect of a Herbal Formula Against Carbontetrachloride Induced Hepatotoxicity

O. Prakash, G.N. Singh, R.M. Singh, S.C. Mathur, M. Bajpai and S. Yadav

International Journal of Pharmacology, 2008, 4(4), 282-286.

Abstract

This study investigated the protective effects of a polyherbal formula BCEZ, containing extracts of Bacopa monneiri Linn. Penn., Curcuma longa Linn., Emblica officinalis Gaertn. and Zingiber officinale Rosc., on the carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Hepatic injury was achieved by injecting 0.5 mL kg-1, i.p. of CCl4. The BCEZ at the doses 50, 100 and 250 mg kg-1, p.o. offered significant hepatoprotective action by reducing the serum marker enzymes like Serum Glutamate Oxaloacetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT). They also reduced the elevated levels of alkaline phosphatase (ALP). Histopathological studies further confirmed the hepatoprotective activity of BCEZ when compared with the CCl4 treated control groups. The results obtained were compared with silymarin (100 mg kg-1, p.o.), the standard drug. Thus it can be concluded, BCEZ might be a potential herbal agent for its hepatoprotective activity.

ASCI-ID: 23-52

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