Research Article
Analgesic Activity of the Different Fractions of the Aerial Parts of Commelina benghalensis Linn

S.M. Raquibul Hasan, M.M. Hossain, R. Akter, M. Jamila, M.E.H. Mazumder, M.A. Alam, A. Faruque, S. Rana and S. Rahman

International Journal of Pharmacology, 2010, 6(1), 63-67.

Abstract

Analgesic potential of the pet ether (PECB), chloroform (CCB), n-butanol (NBCB) and hydromethanolic (HMCB) fractions of the aerial parts of Commelina benghalensis Linn. was evaluated for centrally acting analgesic property using hotplate and tail immersion method and peripheral pharmacological actions using acetic acid-induced writhing test to scientifically validate some of the folkloric and ethnomedical uses of the plant. All fractions, at the dose of 200 and 400 mg kg-1 b.wt., displayed significant analgesic action in a dose dependent manner in the tested models. In acetic acid-induced writhing test, all extracts exhibited significant (p<0.05) reduction of writhing response in a dose dependent manner; the response decreased in the order Diclofenac-Na (76.16%) > CCB2 (68.8%) > NBCB2 (61.9%) > HMCB2 (52.8%) > PECB2 (48.0%). In hotplate and tail immersion method, all fractions caused a significant (p<0.0-0.001) increase in latency time and the results are comparable to the standard drug Nalbuphine. These results suggest significant analgesic potential of C. benghalensis and thereby justify its traditional uses in various types of pain.

ASCI-ID: 23-431

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