Review Article 
Pharmacological Aspects of Psidium guajava: An Update
K.A. Sanda, H.A. Grema, Y.A. Geidam and Y.M. Bukar-Kolo
International Journal of Pharmacology, 2011, 7(3), 316-324.
Abstract
In recent years, the use of herbal products has been increasing in developing countries such as Nigeria. The common guava tree (Psidium guajava) is a medium sized tree belonging to the family Myrtaceae which is native to tropical and subtropical countries. It is popular in an indigenous system of folk medicine. Traditionally guava is used for the treatment of various ailments like diarrhoea wounds, rheumatism, lung problems, ulcers etc. Psidium guajava L. contains a number of major pharmacologically active ingredients such as flavonoids, guayavolic acid, guavanoic acid, guajadial, guajaverin and so many other active principles. This review summarizes the current knowledge of major pharmacological constituents with major emphasis on traditional and pharmacological activities. This plant reported to display various biological activities like antidiarrhoeal, antimicrobial, antioxidant, hepatoprotective, anti-allergy, anti-plasmodial, anti-spasmodic, cardioactive, anti-diabetic, anti-inflammatory anti-nociceptive and antitussive activity. In view of its wide pharmacological and biological activities, it seems to be having a great therapeutic potential.
ASCI-ID: 23-613
Related Articles
Studies on Antipyretic-Analgesic and Ulcerogenic Activity of Polyherbal Preparation in Rats and Mice
International Journal of Pharmacology, 2008, 4(2), 88-94.
Analgesic and Anti-Inflammatory Effects of Ethanolic Root Extract of Hippocratea africanaInternational Journal of Pharmacology, 2008, 4(1), 51-55.
Evaluation of Antipyretic Effect of a Traditional Polyherbal Preparation: A Double-Blind, Randomized Clinical TrialInternational Journal of Pharmacology, 2008, 4(3), 190-195.
Anti-inflammatory, Analgesic and Antipyretic Activities of Dicliptera verticillataInternational Journal of Pharmacology, 2006, 2(4), 435-438.
Mechanism of the Anti-inflammatory Activity of Khaya senegalensis A. Juss. (Meliaceae)International Journal of Pharmacology, 2007, 3(2), 137-142.
Toxicological Effects of Sclerocarya birrea (A. Rich) Hochst (Anacardiaceae) and Psidium guajava L. (Myrtaceae) Leaf Extracts on Mice and Their Pharmacological Effects on Rat DuodenumInternational Journal of Pharmacology, 2006, 2(5), 557-562.
Phytochemical Screening and Antibacterial Properties of Organic Solvent Fractions of Psidium guajava Aqueous Leaf ExtractsInternational Journal of Pharmacology, 2007, 3(1), 68-73.
Cited By
Boerhaavia diffusa Linn.: A Review on its Phytochemical and Pharmacological Profile
Asian Journal of Applied Sciences, 2011, 4(7), 663. DOI: 10.3923/ajaps.2011.663.684
One-Step Multigram-Scale Biomimetic Synthesis of Psiguadial BAngewandte Chemie International Edition, 2017, (), . DOI: 10.1002/anie.201708333
One-Step Multigram-Scale Biomimetic Synthesis of Psiguadial BAngewandte Chemie, 2017, (), . DOI: 10.1002/ange.201708333
Targeted Metabolomic Analysis of Polyphenols with Antioxidant Activity in Sour Guava (Psidium friedrichsthalianum Nied.) FruitMolecules, 2016, 22(12), 11. DOI: 10.3390/molecules22010011
Guava (Psidium guajava L. cv. Red Suprema) Crude Extract Protect Human Dermal Fibroblasts against Cytotoxic Damage Mediated by Oxidative StressPlant Foods for Human Nutrition, 2018, (), . DOI: 10.1007/s11130-018-0657-2
Health Effects of Psidium guajava L. Leaves: An Overview of the Last DecadeInternational Journal of Molecular Sciences, 2017, 18(12), 897. DOI: 10.3390/ijms18040897
Bioactive Compounds Found in Brazilian Cerrado FruitsInternational Journal of Molecular Sciences, 2015, 16(12), 23760. DOI: 10.3390/ijms161023760
The role of pollutants in type 2 diabetes mellitus (T2DM) and their prospective impact on phytomedicinal treatment strategiesEnvironmental Monitoring and Assessment, 2018, 190(5), . DOI: 10.1007/s10661-018-6634-2
Identification of glucosyl transferase inhibitors from Psidium guajava against Streptococcus mutans in dental cariesJournal of Traditional and Complementary Medicine, 2018, (), . DOI: 10.1016/j.jtcme.2017.09.003
Analysis by UPLC-MS-QTOF and antifungal activity of guava ( Psidium guajava L.)Food and Chemical Toxicology, 2018, (), . DOI: 10.1016/j.fct.2018.05.021
Chemical composition and biological activities of the essential oils of Psidium guajava leafJournal of King Saud University - Science, 2018, (), . DOI: 10.1016/j.jksus.2018.07.021
Medicinal Plants Used for the Traditional Management of Diabetes in the Eastern Cape, South Africa: Pharmacology and ToxicologyMolecules, 2018, 23(11), 2759. DOI: 10.3390/molecules23112759
Antidiarrheal and protein conservative activities of Psidium guajava in diarrheal ratsJournal of Integrative Medicine, 2018, (), . DOI: 10.1016/j.joim.2018.12.001
Guava pomace: a new source of anti-inflammatory and analgesic bioactivesBMC Complementary and Alternative Medicine, 2013, 13(1), . DOI: 10.1186/1472-6882-13-235
High Carbohydrate High Fat Diet Induced Hepatic Steatosis and Dyslipidemia Were Ameliorated by Psidium guajava Leaf Powder Supplementation in RatsEvidence-Based Complementary and Alternative Medicine, 2019, 2019(), 1. DOI: 10.1155/2019/1897237
Green and sustainable encapsulation of Guava leaf extracts (Psidium Guajava L.) into alginate/starch microcapsules for multifunctional finish over cotton gauzeACS Sustainable Chemistry & Engineering, 2019, (), . DOI: 10.1021/acssuschemeng.9b04952
Evaluation of Acute and Subacute Toxicities of Psidium guajava Methanolic Bark Extract: A Botanical with In Vitro Antiproliferative PotentialEvidence-Based Complementary and Alternative Medicine, 2019, 2019(), 1. DOI: 10.1155/2019/8306986
Modular Synthesis of Nona‐Decasaccharide Motif from Psidium guajava Polysaccharides: Orthogonal One‐Pot Glycosylation StrategyAngewandte Chemie International Edition, 2020, (), . DOI: 10.1002/anie.202000992
Modular Synthesis of Nona‐Decasaccharide Motif from Psidium guajava Polysaccharides: Orthogonal One‐Pot Glycosylation StrategyAngewandte Chemie, 2020, (), . DOI: 10.1002/ange.202000992
Antioxidative and anti-inflammatory activity of psiguadial B and its halogenated analogues as potential neuroprotective agentsBioorganic Chemistry, 2021, 113(), 105027. DOI: 10.1016/j.bioorg.2021.105027
Transverse Vaginal Septum: A Rare Case diagnosed during LaborInternational Journal of Gynecological Endoscopy, 2017, 1(2), 83. DOI: 10.5005/jp-journals-10058-0020
Choriocarcinoma: Rupture from Uterus with Lung Metastasis—A Rare EntityInternational Journal of Gynecological Endoscopy, 2017, 1(2), 85. DOI: 10.5005/jp-journals-10058-0021
Cesarean Section Scar EndometriosisInternational Journal of Gynecological Endoscopy, 2017, 1(2), 88. DOI: 10.5005/jp-journals-10058-0022
Mayer Rokitansky Küster Hauser SyndromeInternational Journal of Gynecological Endoscopy, 2017, 1(2), 93. DOI: 10.5005/jp-journals-10058-0023
Anatomical Considerations in Implant Selection and PositioningInternational Journal of Oral Implantology & Clinical Research, 2013, 4(1), 24. DOI: 10.5005/JP-Journals-10012-1088
Implants in Diabetic PatientsInternational Journal of Oral Implantology & Clinical Research, 2013, 4(1), 30. DOI: 10.5005/JP-Journals-10012-1089
Protective effects of medicinal plant against diabetes induced cardiac disorder: A reviewJournal of Ethnopharmacology, 2021, 265(), 113328. DOI: 10.1016/j.jep.2020.113328
How does Endometriosis affect Women\'s Life, focusing on Endometriomas?International Journal of Gynecological Endoscopy, 2017, 1(2), 57. DOI: 10.5005/jp-journals-10058-0014
Liberal Use of Intraoperative Cystoscopy in Routine Major Gynecological SurgeriesInternational Journal of Gynecological Endoscopy, 2017, 1(2), 60. DOI: 10.5005/jp-journals-10058-0015
Importance of Colposcopy for screening of Premalignant Lesions of Cervix: An Experience of Tertiary Public Health Hospital in IndiaInternational Journal of Gynecological Endoscopy, 2017, 1(2), 65. DOI: 10.5005/jp-journals-10058-0016
Airway changes in Laboring PatientInternational Journal of Gynecological Endoscopy, 2017, 1(2), 75. DOI: 10.5005/jp-journals-10058-0018
Laparoscopic Tubectomy, Oophorectomy, Adnexectomy: Indications at HysterectomyInternational Journal of Gynecological Endoscopy, 2017, 1(2), 69. DOI: 10.5005/jp-journals-10058-0017
Cervicovaginal Agenesis: Hysterectomy or Uterovaginal Anastomosis?International Journal of Gynecological Endoscopy, 2017, 1(2), 78. DOI: 10.5005/jp-journals-10058-0019
The Tumor Necrosis Factor-Alpha Gene-857 Single-Nucleotide Polymorphism Associated with Early Implant Failure in Asian PatientsInternational Journal of Oral Implantology & Clinical Research, 2011, 2(1), 1. DOI: 10.5005/jp-journals-10012-1028
Luting Agent Effectiveness on Implant Crown RetentionInternational Journal of Oral Implantology & Clinical Research, 2011, 2(1), 7. DOI: 10.5005/jp-journals-10012-1029
Biomaterials for Dental Implants: An OverviewInternational Journal of Oral Implantology & Clinical Research, 2011, 2(1), 13. DOI: 10.5005/jp-journals-10012-1030
Reconstruction of Post-traumatic Anterior Maxillary Osseous Deficits, using Corticocancellous Tibial Graft in Preparation for Implant RehabilitationInternational Journal of Oral Implantology & Clinical Research, 2011, 2(1), 25. DOI: 10.5005/jp-journals-10012-1031
Benefits of CBCT in Implant PlanningInternational Journal of Oral Implantology & Clinical Research, 2011, 2(1), 31. DOI: 10.5005/jp-journals-10012-1032
Sagittal Distraction of Edentulous Maxillary Skeletal Base Prior to Implant TherapyInternational Journal of Oral Implantology & Clinical Research, 2011, 2(1), 37. DOI: 10.5005/jp-journals-10012-1033
A Simplified Approach for Achieving Harmonious Occlusion in Implant Supported Complete Arch Fixed ProsthesisInternational Journal of Oral Implantology & Clinical Research, 2011, 2(1), 43. DOI: 10.5005/jp-journals-10012-1034
Immediate Loading of Implants in the MandibleInternational Journal of Oral Implantology & Clinical Research, 2011, 2(1), 49. DOI: 10.5005/jp-journals-10012-1035
Crestal Sinus Augmentation: A Simplified Approach to Implant Placement in the Posterior MaxillaInternational Journal of Oral Implantology & Clinical Research, 2011, 2(1), 55. DOI: 10.5005/jp-journals-10012-1036
The Peri-Implant Zone: A Review of LiteratureInternational Journal of Oral Implantology & Clinical Research, 2011, 2(2), 61. DOI: 10.5005/jp-journals-10012-1037
Medial Mandibular Flexure: A Review of Concepts and ConsequencesInternational Journal of Oral Implantology & Clinical Research, 2011, 2(2), 67. DOI: 10.5005/jp-journals-10012-1038
Clinicoradiographic Evaluation and Feasibility of Dental Implant in Infected Dentoalveolar SocketInternational Journal of Oral Implantology & Clinical Research, 2011, 2(2), 73. DOI: 10.5005/jp-journals-10012-1039
Histologic and Clinical Evaluation of a Bioactive Calcium Phosphosilicate Bone Graft Material in Postextraction Alveolar SocketsInternational Journal of Oral Implantology & Clinical Research, 2011, 2(2), 79. DOI: 10.5005/jp-journals-10012-1040
Immediate Loading with Intraoral Welding for Improved Implant Stability during HealingInternational Journal of Oral Implantology & Clinical Research, 2011, 2(2), 85. DOI: 10.5005/jp-journals-10012-1041
Mini Dental Implants as a Simple Treatment Alternative for Edentulous Mandibular CasesInternational Journal of Oral Implantology & Clinical Research, 2011, 2(2), 93. DOI: 10.5005/jp-journals-10012-1042
Polyetheretherketone (PEEK) Dental Implants: A Case for Immediate LoadingInternational Journal of Oral Implantology & Clinical Research, 2011, 2(2), 97. DOI: 10.5005/jp-journals-10012-1043
Augmentation Procedures for the Maxillary Sinus: A Case Report with 10-year Follow-upInternational Journal of Oral Implantology & Clinical Research, 2011, 2(2), 105. DOI: 10.5005/jp-journals-10012-1044
Restoration of Congenitally Missing Lateral Incisors with Single Stage Implants: An Interdisciplinary ApproachInternational Journal of Oral Implantology & Clinical Research, 2011, 2(2), 111. DOI: 10.5005/jp-journals-10012-1045
Free Gingival Grafting to Increase the Zone of Keratinized Tissue around ImplantsInternational Journal of Oral Implantology & Clinical Research, 2011, 2(2), 117. DOI: 10.5005/jp-journals-10012-1046
Latest Advances in Concepts and Treatment Protocols of Dental Implants: A Brief ReviewInternational Journal of Oral Implantology & Clinical Research, 2011, 2(3), 121. DOI: 10.5005/jp-journals-10012-1047
Role of Mini-implants in OrthodonticsInternational Journal of Oral Implantology & Clinical Research, 2011, 2(3), 126. DOI: 10.5005/jp-journals-10012-1048
Prevalence of Peri-implant Diseases Associated with a Rough-Surface Dental Implant System: 9 Years after InsertionInternational Journal of Oral Implantology & Clinical Research, 2011, 2(3), 135. DOI: 10.5005/jp-journals-10012-1049
Bite Force Comparison of Implant-retained Mandibular Overdentures with Conventional Complete Dentures: An in vivo StudyInternational Journal of Oral Implantology & Clinical Research, 2011, 2(3), 140. DOI: 10.5005/jp-journals-10012-1050
Practical Application of the Newly Introduced Natural Bone Regeneration (NBR) Concept Utilizing Alloplastic PuttyInternational Journal of Oral Implantology & Clinical Research, 2011, 2(3), 145. DOI: 10.5005/jp-journals-10012-1051
Transfer of Esthetic Gingival Contour for Anterior Implant ProstheticsInternational Journal of Oral Implantology & Clinical Research, 2011, 2(3), 150. DOI: 10.5005/jp-journals-10012-1052
Management of Bisphosphonate-related Osteonecrosis of the Jaw in an Elderly Lebanese FemaleInternational Journal of Oral Implantology & Clinical Research, 2011, 2(3), 155. DOI: 10.5005/jp-journals-10012-1053
Restoration of Maxillary Anterior Defect using Autogenous Block Graft and Optimizing the Esthetics using Zirconia RestorationInternational Journal of Oral Implantology & Clinical Research, 2011, 2(3), 165. DOI: 10.5005/jp-journals-10012-1054
Full-Mouth Implant-supported Rehabilitation with a Flapless Surgical Technique: A Treatment Approach using Computer-Assisted Oral Implant SurgeryInternational Journal of Oral Implantology & Clinical Research, 2011, 2(3), 171. DOI: 10.5005/jp-journals-10012-1055
Timing of Implant Placement in Anterior Zone: A Clinical PerspectiveInternational Journal of Oral Implantology & Clinical Research, 2011, 2(3), 176. DOI: 10.5005/jp-journals-10012-1056
A Comparative Evaluation of Crestal Bone Levels in Mandibular Implant-Retained Overdentures using Delayed and Immediate Loading Protocols: An in vivo StudyInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 1. DOI: 10.5005/JP-Journals-10012-1057
Ridge Preservation done Immediately following Extraction using Bovine Bone Graft, Collagen Plug and Collagen MembraneInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 8. DOI: 10.5005/JP-Journals-10012-1058
A Comparative Evaluation of Linear Dimensional Accuracy of the Dies Obtained using Three Conceptually Different Die Systems in the Fabrication of Implant Prosthesis: An in vitro StudyInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 17. DOI: 10.5005/JP-Journals-10012-1059
Alveolar Ridge Preservation Utilizing the ‘Socket-Plug’ TechniqueInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 24. DOI: 10.5005/JP-Journals-10012-1060
Implantable Devices: A Review of Current Treatment ModalitiesInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 31. DOI: 10.5005/JP-Journals-10012-1061
The Role of Implants in OrthodonticsInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 36. DOI: 10.5005/JP-Journals-10012-1062
Zirconia Abutments in Implant DentistryInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 39. DOI: 10.5005/JP-Journals-10012-1063
Microbiology of Dental Implants: A Review of the LiteratureInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 43. DOI: 10.5005/JP-Journals-10012-1064
Piezosurgical Mandibular Ridge Expansion for Immediate Implant PlacementInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 47. DOI: 10.5005/JP-Journals-10012-1065
Objective Assessment of Implants Stability placed in Fresh Extraction Socket using Periotest DeviceInternational Journal of Oral Implantology & Clinical Research, 2012, 3(2), 67. DOI: 10.5005/jp-journals-10012-1069
PeriimplantitisInternational Journal of Oral Implantology & Clinical Research, 2012, 3(2), 71. DOI: 10.5005/jp-journals-10012-1070
Immediate Load Fiber Reinforced Hybrid Implant ProstheticsInternational Journal of Oral Implantology & Clinical Research, 2012, 3(2), 83. DOI: 10.5005/jp-journals-10012-1072
Rehabilitation of a Patient using a Twin-Stage Technique to achieve Balanced Occlusion in Implant-Supported Overdenture: A Clinical ReportInternational Journal of Oral Implantology & Clinical Research, 2012, 3(2), 92. DOI: 10.5005/jp-journals-10012-1073
Alveolar Ridge Preservation with β-TCP Graft and Platelet-Rich FibrinInternational Journal of Oral Implantology & Clinical Research, 2012, 3(2), 96. DOI: 10.5005/jp-journals-10012-1074
Maxillary Sinus Lift Up: An Indirect Approach for Implant Placement in Posterior MaxillaInternational Journal of Oral Implantology & Clinical Research, 2012, 3(2), 101. DOI: 10.5005/jp-journals-10012-1075
Implant-retained Mandibular Overdentures: A Comparative Study of Immediate Loading vs Delayed Loading after One YearInternational Journal of Oral Implantology & Clinical Research, 2012, 3(3), 105. DOI: 10.5005/JP-Journals-10012-1076
Correlation between Gingival Phenotype, Residual Ridge Height and the Schneiderian MembraneInternational Journal of Oral Implantology & Clinical Research, 2012, 3(3), 111. DOI: 10.5005/JP-Journals-10012-1077
Surface Modifications for Endosseous Dental ImplantsInternational Journal of Oral Implantology & Clinical Research, 2012, 3(3), 116. DOI: 10.5005/JP-Journals-10012-1078
Evolution of External and Internal Implant to Abutment ConnectionInternational Journal of Oral Implantology & Clinical Research, 2012, 3(3), 122. DOI: 10.5005/JP-Journals-10012-1079
Mind the Gap: The Platform Switching ConceptInternational Journal of Oral Implantology & Clinical Research, 2012, 3(3), 130. DOI: 10.5005/JP-Journals-10012-1080
Zirconia Abutments: A Quintessence of Modern Day ImplantologyInternational Journal of Oral Implantology & Clinical Research, 2012, 3(3), 133. DOI: 10.5005/JP-Journals-10012-1081
Immediate Implant Placement in Maxillary Molars using Septa Dilatation with Threaded Expanders: 3 Years Follow-up and use of the Technique in Complex CasesInternational Journal of Oral Implantology & Clinical Research, 2012, 3(3), 138. DOI: 10.5005/JP-Journals-10012-1082
Alveolar Reconstruction using Osteointegrated Mini-implant for Distraction Osteogenesis: A Clinical ReportInternational Journal of Oral Implantology & Clinical Research, 2012, 3(3), 146. DOI: 10.5005/JP-Journals-10012-1083
Single-Stage Dental Implant Placement with Indirect Sinus Floor Elevation Technique: A Clinical ReportInternational Journal of Oral Implantology & Clinical Research, 2012, 3(3), 150. DOI: 10.5005/JP-Journals-10012-1084
Evaluation of Active Tactile Perception of Single Tooth Implant ProsthesisInternational Journal of Oral Implantology & Clinical Research, 2013, 4(1), 1. DOI: 10.5005/JP-Journals-10012-1085
Immediate Placement Implant in Fresh Extraction Socket: A Clinical Study of Seven CasesInternational Journal of Oral Implantology & Clinical Research, 2013, 4(1), 7. DOI: 10.5005/JP-Journals-10012-1086
Influence of Occlusal Forces on Stress Distribution on Preloaded Dental Implant Abutment Screws: A Finite Element Analysis StudyInternational Journal of Oral Implantology & Clinical Research, 2013, 4(1), 16. DOI: 10.5005/JP-Journals-10012-1087
In-vitro and in-silico evaluation of the anti-chikungunya potential of Psidium guajava leaf extract and their synthesized silver nanoparticlesVirusDisease, 2021, (), . DOI: 10.1007/s13337-021-00685-4
‘Teeth in a Day’—An Innovative, Cost-Effective Technique for Immediate Loading of ImplantsInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 51. DOI: 10.5005/JP-Journals-10012-1066
Attitude toward Desire for Implant Treatment in South Coastal Karnataka Population: A Short-term Epidemiological SurveyInternational Journal of Oral Implantology & Clinical Research, 2012, 3(2), 63. DOI: 10.5005/jp-journals-10012-1068
Comparative Evaluation of the Efficacy of Calcium Sulfate Bone Grafts in Crystalline and Nano-Crystalline Forms in Fresh Extraction Socket Sites: A Radiographic and Histological Pilot StudyInternational Journal of Oral Implantology & Clinical Research, 2012, 3(1), 58. DOI: 10.5005/JP-Journals-10012-1067
Tissue Stability following Soft-tissue Augmentation and Zirconia Prosthesis: A 6 Years Follow-upInternational Journal of Oral Implantology & Clinical Research, 2012, 3(2), 77. DOI: 10.5005/jp-journals-10012-1071
Phytochemistry, the Military and HealthPhytochemistry, the Military and Health, 2021, (), 353. DOI: 10.1016/B978-0-12-821556-2.00027-X
Comparison of changes in salivary ph after chewing guava leaves (Psidium Guajava) and xylitol gum: A randomized, single-blind, crossover studyJournal of Indian Association of Public Health Dentistry, 2021, 19(2), 135. DOI: 10.4103/jiaphd.jiaphd_134_20
Innovative approach for obtaining phenolic compounds from guava (Psidium guajava L.) coproduct using ionic liquid ultrasound-assisted extraction (IL-UAE)Biocatalysis and Agricultural Biotechnology, 2021, (), 102196. DOI: 10.1016/j.bcab.2021.102196
The Antibacterial and Coagulant Activity of Psidium Guajava Leaves Extracts in Purification of WastewaterBiosciences, Biotechnology Research Asia, 2020, 17(1), 191. DOI: 10.13005/bbra/2823
Valorization of Guava Fruit Byproducts: Chemical Composition, Bioactive Components, and Technical Concerns to the Food IndustryMediterranean Fruits Bio-wastes, 2022, (), 819. DOI: 10.1007/978-3-030-84436-3_35