Research Article 
Antidiabetic and Oxidative Stress Ameliorative Potential of
Ethanolic Extract of Pedicularis longiflora Rudolph
Mohd. Iqbal Yatoo, Umesh Dimri, Arumugam Gopalakrishan, Mani Saminathan, Kuldeep Dhama, Karikalan Mathesh, Archana Saxena, Devi Gopinath and Shahid Husain
International Journal of Pharmacology, 2016, 12(3), 177-187.
Abstract
This study demonstrated the antidiabetic and antioxidant potential of Pedicularis longiflora Rudolph, a Himalayan wild herb, in alloxan induced diabetic rats. Seven groups of wistar rats (n = 6) were divided into healthy control (I) and diabetic control (II) groups, both without any treatment, test groups (III, IV and V) treated with varying concentration of ethanolic extract of Pedicularis longiflora and standard groups treated with N-acetyl cysteine as standard antioxidant (VI) and glibenclamide as standard antidiabetic drug (VII). Diabetic biomarkers and oxidative stress indices were evaluated on day 0, 7 and 14 of treatment. Glucose, glycated haemoglobin (GHb) and fructosamine showed a decrease of 23.08, 33.85 and 43.46%, respectively in group IV than group III (15.06, 46.13 and 23.95%) and group V (15.99, 27.77 and 24.84%) whereas, insulin showed significant (p<0.05) increase in group IV (15.43%) and group V (5.12%), but not than group III (16.82%) on day 14 of treatment. Concentration of reduced glutathione (GSH) and activity of superoxide dismutase (SOD) was increased (p<0.05) whereas, levels of lipid peroxide (LPO) and Nitric Oxide (NO) were decreased (p<0.05) in test groups on day 14 of treatment compared to diabetic control group. Liver homogenate showed lower levels (p<0.05) of LPO and NO, whereas, pancreatic homogenate showed higher levels (p<0.05) of GSH and lower levels (p<0.05) of LPO in test groups. These findings can be attributed to antidiabetic and antioxidant potential of P. longiflora Rudolph, however, group IV (500 mg kg–1 b.wt.) showing better response indicating its safe use as natural medicine.
ASCI-ID: 23-1047
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Effectiveness of Moringa oleifera L. Leaves Extract Against Methotrexate-induced Acute Hepatotoxicity in Male RatsInternational Journal of Pharmacology, 2018, 14(7), 1029-1037.
Effectiveness of Osthole on Uric Acid Crystal-induced Acute Gouty Arthritis Through the Inhibition of NLRP3 InflammasomeInternational Journal of Pharmacology, 2018, 14(8), 1169-1178.
Anti-diabetic Potential of Cordia dichotoma Pulp and Peel (Functional Fiber) in Type II Diabetic RatsInternational Journal of Pharmacology, 2019, 15(1), 102-109.
Ameliorative and Synergistic Effect of Red Raspberry and Lycopene Against Hepatotoxicity Induced by Acrylamide in Male MiceInternational Journal of Pharmacology, 2019, 15(2), 166-176.
Potential Antioxidant, Anti-Inflammatory and Gastroprotective Effect of Grape Seed Extract in Indomethacin-induced Gastric Ulcer in RatsInternational Journal of Pharmacology, 2019, 15(2), 209-218.
Counteractive Role of White Pepper Extracts for Oxidative Stress and Hepatotoxicity Induced by Aflatoxin B1 in RatsInternational Journal of Pharmacology, 2019, 15(2), 177-188.
Histopathological Effect of Aspartame on Liver and Kidney of MiceInternational Journal of Pharmacology, 2019, 15(3), 336-342.
Aqueous Green Tea Extract and Prediction of Fibrosis in Lipopolysaccharide Intoxicated RatsInternational Journal of Pharmacology, 2019, 15(3), 403-417.
Protective Activity of Taurine and Molecular Fibrogenesis in Iron Overloaded Hepatic TissuesInternational Journal of Pharmacology, 2019, 15(3), 418-427.
Inhibitory Effect of Grape Seed Polyphenol Extract and Vitamin C on Melanogenesis in Cultured B16-F1 Melanoma CellsInternational Journal of Pharmacology, 2019, 15(5), 533-541.
Reverse of β-Amyloid Induced Apoptosis in PC12 Cells by Nattokinase: Role of SIRT1-ROCK1 PathwayInternational Journal of Pharmacology, 2019, 15(5), 593-603.
Protective and Antioxidant Role of Selenium Nanoparticles and Vitamin C Against Acrylamide Induced Hepatotoxicity in Male MiceInternational Journal of Pharmacology, 2019, 15(6), 664-674.
Evaluation of Antioxidative Effect of Green Tea Catechins Against Isoniazid-induced Biochemical Alterations in RatsInternational Journal of Pharmacology, 2019, 15(7), 777-789.
Barbaloin Ameliorates the Memory in Isoflurane Induced Neuronal Injury by Regulating the BDNF/Bcl-2/PI3K Signaling PathwayInternational Journal of Pharmacology, 2019, 15(7), 801-808.
Effect of Datura stramonium on Cyclophosphamide-induced Oxidative Stress in Albino Rats: Study on Kidney MarkersInternational Journal of Pharmacology, 2019, 15(8), 926-932.
Protective Effect of Celastrol on Gentamicin-induced Nephrotoxicity in MiceInternational Journal of Pharmacology, 2020, 16(2), 126-135.
Camel Urine Prevents Cisplatin-induced Nephrotoxicity in Rats by Attenuating Oxidative Stress and ApoptosisInternational Journal of Pharmacology, 2020, 16(3), 257-266.
Prevention of Metabolic, Redox and Lipid Biosynthesis Alterations by Visnagin in High Cholesterol-Fed RatsInternational Journal of Pharmacology, 2020, 16(5), 398-406.
Effect of Resveratrol on Neurotrophic Factors and Depression-Like Behavior in a Rat Model of Male HypogonadismInternational Journal of Pharmacology, 2021, 17(1), 38-47.
Protective Effect of Nicotiana plumbaginifolia Linn against CCl4 Induced Oxidative Stress in Gallus gallusdomesticusInternational Journal of Pharmacology, 2021, 17(3), 130-137.
Valproate Ameliorates Diethylnitrosamine/Phenobarbital- Induced Hepatic Cancer via the Role of TNF-α and TGF-β1International Journal of Pharmacology, 2021, 17(4), 156-168.
Molecular and Histological Study of Low Molecular Weight Heparin’s Effect Against Cerebral Ischemic InjuryInternational Journal of Pharmacology, 2021, 17(4), 190-199.
Chlorogenic Acid Improves Cognitive Deficits in Diabetic RatsInternational Journal of Pharmacology, 2021, 17(6), 370-379.
Alpha-Pinene Induces Apoptosis through Oxidative Stress and PI3K/AKT/NF-κB Signalling Pathway in MDA-MB-231 Human Breast Cancer CellsInternational Journal of Pharmacology, 2021, 17(6), 391-399.
Triphala Suppresses Ovarian Cancer Cell Proliferation through Induction of Apoptosis and ROS in vitroInternational Journal of Pharmacology, 2021, 17(7), 491-498.
Astilbin Prevents Neuroinflammation and Mitigates Cognitive Deficits in Lipopolysaccharides Induced Peripheral InfectionInternational Journal of Pharmacology, 2022, 18(1), 60-69.
Arctigenin Alleviates Oxidative Stress in Cerebral Ischemia/ Reperfusion Injury Rats by Keap1-Nrf2 PathwayInternational Journal of Pharmacology, 2021, 17(7), 464-473.
Dipsacus asperoides Extract Improves Physiological Behaviour and Controls Oxidative Stress Produced by a Rat Model of OsteoarthritisInternational Journal of Pharmacology, 2022, 18(4), 598-610.
Perioperative Effects of Hydromorphone in Gynecological Laparoscopic Surgery under General AnesthesiaInternational Journal of Pharmacology, 2022, 18(3), 534-542.
Asiatic acid Improves Physical Fatigue through Regulating Inflammatory Reaction, Oxidative Stress and Energy Metabolism in MiceInternational Journal of Pharmacology, 2022, 18(4), 783-793.
Beneficial Effects of Tofacitinib in Long-Standing Diabetes-Induced Cognitive Impairment in Rats through BDNF-TNF-α-Nrf2 Signalling PathwayInternational Journal of Pharmacology, 2022, 18(5), 856-863.
Neuroprotective Effects of Different Lavandula stoechas L. Extracts Against Hydrogen Peroxide Toxicity in vitroInternational Journal of Pharmacology, 2022, 18(5), 883-896.
Inhibitory Effect of Methotrexate (MTX) Used in Human Cancer Treatment on Paraoxonase-1 (PON1)International Journal of Pharmacology, 2022, 18(5), 942-946.
Gastrodiae Rhizoma Improve Cognitive Functions and Regulate Keap1/Nrf2-ARE Signal Pathway in APP/PS1 Transgenic MiceInternational Journal of Pharmacology, 2022, 18(6), 1101-1115.
Earthworm Extract Exhibits Therapeutic Effect Against Epinephrine-Induced Myocardial Infarction in RatsInternational Journal of Pharmacology, 2022, 18(6), 1126-1136.
Significance of LncRNA NEAT1 Alterations During Treatment of Nonalcoholic Fatty Liver Disease and its Association with Gut MicrobiotaInternational Journal of Pharmacology, 2022, 18(6), 1287-1295.
Influence of Nervonic Acid on Parkinson’s Disease Model Cells through Ras/MEK/ERK AxisInternational Journal of Pharmacology, 2022, 18(6), 1309-1321.
Is Benidipine Effective in Preventing Gastric Ischemia/ Reperfusion Injury?International Journal of Pharmacology, 2022, 18(6), 1271-1277.
Effect of Thymoquinone on Diclofenac-Induced Liver InjuryInternational Journal of Pharmacology, 2022, 18(6), 1331-1339.
Asiatic Acid Ameliorates Cognitive Impairment in Diabetic RatsInternational Journal of Pharmacology, 2022, 18(7), 1500-1508.
Anti-Inflammatory and Antioxidant Effects of Chrysin Mitigates Diabetic Foot UlcersInternational Journal of Pharmacology, 2023, 19(1), 122-130.
Protective Effect of Fangchinoline Against Glaucoma and Neuroinflammation in Unilateral Ocular Hypertension in MiceInternational Journal of Pharmacology, 2023, 19(1), 131-138.
Nasal Oxytocin’s Anticonvulsant Effects on Pentylenetetrazol- induced Convulsions in RatsInternational Journal of Pharmacology, 2023, 19(2), 178-184.
Therapeutic Efficacy of Anodonta cygnea and Crayfish Procambarus clarkii Hemolymph Extracts on Sepsis-Induced Acute Liver Injury in Neonate RatsInternational Journal of Pharmacology, 2023, 19(2), 185-196.
Ellagic Acid Protects Against Fatigue in Exercise Trained MiceInternational Journal of Pharmacology, 2023, 19(2), 197-205.
Potent Protective Effect of Lacidipine, Carvacrol and Lacidipine-Carvacrol Combination Against 5-Fluorouracil-Induced Cardiotoxicity in RatsInternational Journal of Pharmacology, 2023, 19(3), 321-328.
Metformin and Resveratrol Suppress Oxidative Stress/Hypoxia Axis Associated with the Amelioration of Thioacetamide-Induced Liver InjuryInternational Journal of Pharmacology, 2023, 19(3), 439-446.
Effect of the Methanolic Extract of Algerian Salvia officinalis L. Against Oxidative Stress Associated with Diabetes MellitusInternational Journal of Pharmacology, 2023, 19(6), 784-794.
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