Rifat Ullah Khan, Shabana Naz, Kuldeep Dhama, K. Karthik, Ruchi Tiwari, Mutassim M. Abdelrahman, Ibrahim A. Alhidary and Arshad Zahoor
International Journal of Pharmacology, 2016, 12(3), 220-231.
Recently, animal food industry has shown an increasing interest in Direct-Fed Microbials (DFM) to keep the concept of safe food supply at the consumer level. In the absence of suitable growth stimulant after banning the use of antibiotics in animal feed, a positive manipulation of rumen microbes has become the field research for entrepreneurs and research scientists. Direct-fed microbials is a term reserved for naturally occurring live microbes that can be supplemented orally to produce a beneficial health response in the host animal. A number of genera of live microorganisms including; bacteria, yeast and fungi are frequently used in different combination feed as DFM for domestic ruminants. It has been documented that these live culture of microbes improve ruminant productivity, milk production, immunity, digestibility of feed, counter infectious pathogens and protect health. Possible attempts have also been undertaken to justify the mechanism of these microbes. This review tries to summarize the effect of supplementation of DFM on the production, immune response, fermentation pattern and safeguarding health. The discussed concepts and advances concerning to DFM implementation will be useful not only for the researchers, animal owners, feed manufacturers, pharmacists, pharmaceutical companies, stake holders but will also boost the economic gains and profits by promoting the ruminant health and production through feed modification.
ASCI-ID: 23-1048
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Veterinary Quarterly, 2017, 37(1), 136. DOI: 10.1080/01652176.2017.1323355
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Alternatives to antibiotics in poultry feed: molecular perspectivesCritical Reviews in Microbiology, 2017, (), 1. DOI: 10.1080/1040841X.2017.1373062
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The effect of some natural alternative to antibiotics on growth and changes in intestinal histology in broiler exposed to Salmonella challengePoultry Science, 2018, (), . DOI: 10.3382/ps/pey449
The benefits of supplementation with antibiotic alternatives on Newcastle disease virus titres in poultryWorld`s Poultry Science Journal, 2018, 74(4), 665. DOI: 10.1017/S0043933918000533
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Single or Combined Applications of Zinc and Multi-strain Probiotic on Intestinal Histomorphology of Broilers Under Cyclic Heat StressProbiotics and Antimicrobial Proteins, 2019, (), . DOI: 10.1007/s12602-019-09561-6
Influence of feeding with live yeast on cow productivity and milk qualityTehnologìâ virobnictva ì pererobki produktìv tvarinnictva, 2018, (2), 32. DOI: 10.33245/2310-9289-2018-145-2-32-37
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Meat safety and quality: a biological approachInternational Journal of Food Science & Technology, 2020, (), . DOI: 10.1111/ijfs.14602
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Probiotics mitigating subclinical necrotic enteritis (SNE) as potential alternatives to antibiotics in poultryAMB Express, 2020, 10(1), . DOI: 10.1186/s13568-020-00989-6
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The Recent Trend in the Use of Multistrain Probiotics in Livestock Production: An OverviewAnimals, 2021, 11(10), 2805. DOI: 10.3390/ani11102805
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The addition of feed additive in beef cattle ration on in vitro fermentation characteristicsIOP Conference Series: Earth and Environmental Science, 2021, 888(1), 012074. DOI: 10.1088/1755-1315/888/1/012074
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Influence of microbial probiotics on ruminant health and nutrition: sources, mode of action and implicationsJournal of the Science of Food and Agriculture, 2021, (), . DOI: 10.1002/jsfa.11643
Carryover effect of direct-fed microbial supplementation and early weaning on the growth performance and carcass characteristics of growing Najdi lambsOpen Chemistry, 2021, 19(1), 1274. DOI: 10.1515/chem-2021-0116
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Cassava pulp can be nutritionally improved by yeast and various crude protein levels fed to cattleAnimal Production Science, 2022, 62(4), 333. DOI: 10.1071/AN20523
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