Search. Read. Cite.

Easy to search. Easy to read. Easy to cite with credible sources.

Research Article
Effect of Roasted Date Palm Rich Oil Extracts in Liver Protection and Antioxidant Restoration in CCl4-induced Hepato Toxicity in Rats

Hussein M. Eldeeb, Hamdoon A. Mohammed, Mohammed S. M. Sajid, Salah Elnaeem M. Eltom, Mohsen S. Al-Omar, Mugahid A. Mobark and Amira S. Ahmed

International Journal of Pharmacology, 2020, 16(4), 367-374.

Abstract

Background and Objectives: Roasted date palm seeds are commercially available in the markets and used as hot-coffee drink-substitute and traditionally in the treatment of male infertility. This study aimed to evaluate the lipid profile, hepatoprotective, in vivo antioxidant activities of roasted date palm rich oil extracts on carbon tetrachloride (CCl4) induced oxidative liver injury in rats. Materials and Methods: Rats were divided into 5 groups (n = 5), placebo (G1), rats received CCl4 (G2), rats received CCl4 and silymarin (G3), rats received CCl4 and roasted date palm seed hexane extract (RDPHE) (G4) and rats received CCl4 and roasted date palm seeds chloroform extract (RDPCE) (G5). Liver functions and lipid profile were determined by spectrophotometric assays. The superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were assayed by ELISA. Results: Both extracts of roasted seeds significantly decreased ALT level compared to G2 and significantly improved total cholesterol compared to both G2 and G3. The activity of SOD and GPx were significantly enhanced in G3, G4 and G5 compared to G2. Significant negative correlations of ALT with total cholesterol and HDL-C and also between ALP and LDL-C were recorded. Clear preservation of tissue architecture, intact hepatocytes, disappearance of tissue necrosis, fibrosis and marked reduction in inflammatory cellular infiltration were observed in the liver tissues of the treated groups. Conclusion: In conclusion, RDPHE and RDPCE enhanced the antioxidant enzymes activity and have ameliorative effects against CCl4-induced hepatic injury in rats. The significant negative correlation was observed between liver enzymes (ALT, ALP) and lipid profile.

ASCI-ID: 23-1583

Cited References Fulltext

Related Articles


Screening of Anti-Arthritic, Anti-Inflammatory and Analgesic Activity of a Polyherbal Formulation

International Journal of Pharmacology, 2008, 4(5), 398-402.

Role of Zinc in the Protection Against Cadmium Induced Hepatotoxicity

International Journal of Pharmacology, 2006, 2(1), 79-88.

Effect of Dietary Supplementation of Ellataria cardamomum and Nigella sativa on the Toxicity of Rancid Corn Oil in Rats

International Journal of Pharmacology, 2006, 2(1), 60-65.

The Effects of Sodium Arsenite on the Biochemical Factors in the Blood of Vasectomised Rats

International Journal of Pharmacology, 2006, 2(5), 525-529.

Screening of Anti-Arthritic, Anti-Inflammatory and Analgesic Activity of a Polyherbal Formulation

International Journal of Pharmacology, 2008, 4(5), 398-402.

Role of Zinc in the Protection Against Cadmium Induced Hepatotoxicity

International Journal of Pharmacology, 2006, 2(1), 79-88.

The Effects of Sodium Arsenite on the Biochemical Factors in the Blood of Vasectomised Rats

International Journal of Pharmacology, 2006, 2(5), 525-529.

Acute Toxicity Studies and Psychopharmacological Effects of Eucalyptus globulus Leaf Oil in Rodents

International Journal of Pharmacology, 2022, 18(4), 673-681.

Modulation of Restraint Induced Gastric Oxidative Changes in Rats by Tocotrienol and Tocopherol

International Journal of Pharmacology, 2009, 5(1), 58-64.

Cellular Defense Enzyme Profile for Non-cytotoxic and Phenol Enriched Extracts of Heliotropium europaeum, Carlina oligocephala and Echinops ritro

International Journal of Pharmacology, 2018, 14(2), 224-238.

Hepatic Gene Expression, Antioxidant Enzymes and Anti-diabetic Effect of Nigella sativa in Diabetic Rats

International Journal of Pharmacology, 2019, 15(2), 265-273.

Effect of Datura stramonium on Cyclophosphamide-induced Oxidative Stress in Albino Rats: Study on Kidney Markers

International Journal of Pharmacology, 2019, 15(8), 926-932.

Some NSAIDs Offer Antioxidant Effect in the Brain Only in Combination with Other Antioxidant Products

International Journal of Pharmacology, 2021, 17(6), 350-357.

Chemoprotective Effect of Ginsenoside Against the 1,2-Dimethylhydrazine (DMH) Induced Colorectal Cancer in Rats

International Journal of Pharmacology,

Hepatoprotective and Antioxidant Action of Moringa oleifera Lam.Against Acetaminophen Induced Hepatotoxicity in Rats

International Journal of Pharmacology, 2008, 4(4), 270-275.

Protective Effect of a Herbal Formula Against Carbontetrachloride Induced Hepatotoxicity

International Journal of Pharmacology, 2008, 4(4), 282-286.

Hepatoprotective Effect of Enicostemma littorale blume and Eclipta alba During Ethanol Induced Oxidative Stress in Albino Rats

International Journal of Pharmacology, 2009, 5(4), 268-272.

Antioxidant and Hepatoprotective Potential of Stem Methanolic Extract of Justicia gendarussa Burm

International Journal of Pharmacology, 2010, 6(2), 72-80.

Evaluation of Hepatic Microsomal Enzyme Functional Integrity on Picroliv Pretreatment Against CCl4 Induced Hepatotoxicity

International Journal of Pharmacology, 2010, 6(3), 200-207.

Hepatoprotective and Antioxidant Activity of Root Bark of Calotropis procera R.Br (Asclepediaceae)

International Journal of Pharmacology, 2010, 6(6), 937-943.

Study of Hepatoprotective Activity of Solanum nigrum and Cichorium intybus

International Journal of Pharmacology, 2011, 7(4), 504-509.

Onion (Allium cepa L.): An Alternate Medicine For Pakistani Population

International Journal of Pharmacology, 2011, 7(6), 736-744.

Piperine and Quercetin Enhances Antioxidant and Hepatoprotective effect of Curcumin in Paracetamol Induced Oxidative Stress

International Journal of Pharmacology, 2012, 8(2), 101-107.

In vitro and in vivo Antidiabetic and Antiglycation Properties of Apium graveolens in Type 1 and 2 Diabetic Rat

International Journal of Pharmacology, 2014, 10(7), 368-379.

Protective Effect of Byrsonima sericea Extract on Non-alcoholic Fatty Liver Disease Model in Rats

International Journal of Pharmacology, 2019, 15(5), 567-575.

Effect of Hexane Extract of Cassia fistula Barks on Blood Glucose and Lipid Profile in Streptozotocin Diabetic Rats

International Journal of Pharmacology, 2008, 4(4), 292-296.

Dyslipidemia Induced by Atenolol in Common Rabbits Oryctolagus cuniculus

International Journal of Pharmacology, 2006, 2(5), 553-556.

Antihyperglycemic, Hypolipidemic and Antioxidant Enzymes Effect of Strobilanthes crispus Juice in Normal and Streptozotocin-Induced Diabetic Male and Female Rats

International Journal of Pharmacology, 2009, 5(3), 200-207.

A Comparative Study of the Effects of Clozapine and Risperidone Monotherapy on Lipid Profile in Nigerian Patients with Schizophrenia

International Journal of Pharmacology, 2012, 8(3), 169-176.

A Systematic Review about Effects of Aerial Portions of Urtica dioica (Nettle) on Some Cardiovascular Risk Factors in Diabetes Mellitus

International Journal of Pharmacology, 2012, 8(5), 306-313.

Effects of Aqueous Extract of Nauclea latifolia Stem on Lipid Profile and Some Enzymes of Rat Liver and Kidney

International Journal of Pharmacology, 2012, 8(5), 389-395.

Anti-Obesity Effects of Extracts from Sulfur-Grain Maggot In Obesity Model Rats

International Journal of Pharmacology, 2015, 11(5), 414-422.

Antioxidant Properties of Citrus macroptera Fruit and Its in vivo Effects on the Liver, Kidney and Pancreas in Wistar Rats

International Journal of Pharmacology, 2015, 11(8), 899-909.

Antioxidant, Antidiabetic and Antihyperlipidemic Effects of Trigonella foenum-graecum Seeds

International Journal of Pharmacology, 2016, 12(4), 394-400.

Anti-hyperglycemic and Anti-hyperlipidemic Effects of Lupinus albus in Type 2 Diabetic Patients: A Randomized Double-blind, Placebo-controlled Clinical Trial

International Journal of Pharmacology, 2016, 12(8), 830-837.

Hesperidin Exerts the Gestational Diabetes Mellitus via AGEs-RAGE Signalling Pathway

International Journal of Pharmacology, 2019, 15(5), 604-615.

Levonorgestrel and Desogestrel Modulate Gut Microbiota and Blood Biochemistry of Female Wistar Rats

International Journal of Pharmacology, 2022, 18(4), 826-841.

Effect of Iodine Supplementation on Antioxidant Status of Normal and Alloxan Monohydrate in Toxicated Rats

International Journal of Pharmacology, 2011, 7(6), 726-731.

Phytochemical Evaluation and Antioxidant Potential of Garcinia indica Fruits on H2O2 Induced Oxidative Stress in THP-1 Cell Line

International Journal of Pharmacology, 2015, 11(7), 672-680.

Cellular Defense Enzyme Profile for Non-cytotoxic and Phenol Enriched Extracts of Heliotropium europaeum, Carlina oligocephala and Echinops ritro

International Journal of Pharmacology, 2018, 14(2), 224-238.

Antioxidant Activity of Lawsone and Prediction of its Activation Property on Superoxide Dismutase

International Journal of Pharmacology,