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Research Article
CFD Simulation of the Flow in Jet-swirl Nozzle for Preparing Nano-drug During a SEDS Process

Kefeng Xiao, Zhihui Hao, Dedong Hu and Leilei Wang

Journal of Applied Sciences, 2013, 13(5), 722-728.

Abstract

Solution Enhanced Dispersion by Supercritical fluid (SEDS) process is utilized more and more widely for preparing nano-drug. Nozzle is the key component in SEDS process. In this study, the flow in jet-swirl nozzle for preparing nano-drug in SEDS process was analyzed by Computational Fluid Dynamics (CFD). It can be concluded from the results that the jet mixing length was found to be a strong function of the volume flow of supercritical CO2 (SC-CO2) at the inlet of the swirl chamber. When the volume flow of SC-CO2 was equal to or greater than 25 mL min-1, methylene chloride and SC-CO2 mixed completely in the nozzle. These results were coincident with the results obtained from experiments in literature. In additional, it also was indicated that the turbulent intensity at the outlet was all even in different volume flow of SC-CO2 and with the increase of volume flow of SC-CO2, the turbulent intensities at the outlet become greater and greater. These results were similar with the results obtained from experiments in literature. By these CFD analysis and comparison with literature, the flow parameters in jet-swirl nozzle were revealed and the method of CFD analysis for SEDS process was validated.

ASCI-ID: 35-4849

Cited References Fulltext

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