Research Article 
Diet Supplementation of Silymarin Increased the Antioxidantive Capacity in Cumene Hydroperoxide-Challenged Ducks
Dan Yi, Cong Wang, Danfeng Sun, Yongqing Hou, Binying Ding, Lei Wang and Joshua Gong
Journal of Animal and Veterinary Advances, 2012, 11(16), 2986-2994.
Abstract
This study was conducted to investigate the efficacy of Silymarin (SIL) as antioxidant against Cumene Hhydroperoxide (CH) induced oxidative damage in liver and intestinal mucosa of ducks. One hundred and sixty male Cherry Valley ducks (28 days old) were randomly allotted to control, CH, CH + 100 SIL (100 mg kg-1 diet) and CH + 200 SIL (200 mg kg-1 diet) groups. At the age of 42 days, ducks in CH, CH + 100 SIL and CH + 200 SIL groups received intraperitoneal administration of CH (30 mg kg-1 BW) whereas ducks in the control group received the same volume of sterile saline for 5 consecutive days. At the age of 50 days, the blood samples were collected and ducks were killed to obtain liver and intestine for analysis. Compared with the control group, CH challenge increased the levels of plasma Glutamic-Pyruvic Transaminase (GPT), Alkaline Phosphatase (AKP), hepatic and Mucosal Malondialdehyde (MDA) (p<0.05) but reduced the levels of Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione S-Transferase (GST) in liver (p<0.05). CH-treated ducks exhibited a higher crypt depth (p<0.05) and a lower concentration of protein, RNA, DNA and the activities of sucrase and maltase in intestine mucosa (p<0.05). These adverse effects of CH were attenuated (p<0.05) by supplementation of SIL, particularly at the dosage of 200 mg kg-1 diet. These data suggest that dietary supplement with 200 mg kg-1 SIL alleviates hepatic oxidative injury and improves intestinal absorptive capacity in CH-challenged ducks.
ASCI-ID: 156-3667
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