M.R. Amin, M. Mostofa, K. Rafiq, M.S. Hossain, M.M. Hasan and M.L. Sharmin
Journal of Biological Sciences, 2004, 4(3), 323-326.
The research work was carried out to investigate the effects of oral administration of glucocorticoids (dexamethasone and prednisolone), NSAIDs (aspirin and paracetamol) and sulfonylureas (gliclazide and glibenclamide) on body weight and blood glucose in mice. Out of seven groups of mice (each containing 5 mice), one group was kept as control without giving any drug. Another six groups of mice received separately dexamethasone (Oradexon®, 3.5 mg kg-1 b.wt.) prednisolone (Deltasone®, 8 mg kg-1 b.wt.), aspirin (Ecospirin®, 620 mg kg-1 b.wt.), paracetamol (Napa®, 333 mg kg-1 b.wt.), gliclazide (Comprid®, 64 mg kg-1 b.wt.) and glibenclamide (Glucotab®, 16 mg kg-1 b.wt) orally along with normal feed. A significant (p<0.05) reduction of body weight was recorded on 7th day following administration of dexamethasone, gliclazide and glibenclamide in mice. This reduction was highly significant (p<0.01) on 21st, 42nd and 70th day following dexamethasone, gliclazide and glibenclamide treated groups. Similarly prednisolone significantly (p<0.01) reduced body weight of mice in whole experimental period. A significant (p<0.01) increase of the blood glucose level was found due to dexamethasone, prednisolone, aspirin and paracetamol administration on 7th , 21st, 42nd and 70th day. On the other hand, a significant (p<0.01) decrease of blood glucose level was found in mice treated with gliclazide and glibenclamide in whole experimental period. It may be concluded that oral administration of glucocorticoids, NSAIDs and sulfonylureas have variable effects on blood glucose level in mice.
Journal of Biological Sciences, 2003, 3(10), 875-881.Caesalpinia pulcherrima Extracts on Blood Glucose in Normal and Alloxan Monohydrate-induced Diabetic Rats
Journal of Biological Sciences, 2019, 19(1), 34-39.Effects of Subcutaneous Injection in Mice with Oral Prevotella intermedia Clinical Isolates in Malaysia
Journal of Biological Sciences, 2005, 5(6), 828-831.Effect of Photoperiodism and Food Rations on the Population Density of the Albino Mice
Journal of Biological Sciences, 2008, 8(1), 161-165.Antioxidation and Hypomethylation Effects on Genotoxicity and Programmed Cell Death Induced in Mice Somatic Cells by Arsenic Trioxide
Journal of Biological Sciences, 2009, 9(7), 721-729.Physiological Vulnerability to Diet Induced Obesity in Inbred Alloxan-Induced Diabetes-Susceptible Mice
Journal of Biological Sciences, 2008, 8(2), 421-425.Effect of the Antioxidant Butylated Hydroxytoluene on the Genotoxicity and Cytotoxicity Induced in Mice by Sodium Arsenite
Journal of Biological Sciences, 2009, 9(5), 413-422.Hematological, Physiological, Histopathological and Immunological Effects of Pinworm (Aspiculuris tetraptera) Infection in Laboratory Mice
Journal of Biological Sciences, 2021, 21(1), 10-18.