Research Article
Effect of Cinnamon on Plasma Glucose Concentration and the Regulation of 6-phosphofructo-1-kinase Activity from the Liver and Small Intestine of Streptozotocin Induced Diabetic Rats

Soonham S. Yaghmoor and Samir M. Khoja

Journal of Biological Sciences, 2010, 10(8), 761-766.


The effect of cinnamon on plasma glucose concentration and the regulation of 6- Phosphofructo-1-Kinase (PFK-1) in the liver and small intestine of streptozotocin-induced diabetic rats were investigated. Concentration of glucose, free and esterfied cholesterol, triacylglycerol was estimated colorimetrically. Concentration of insulin was measured with Roche Diagnostics GmbH Ultrasensetive Rat Insulin ELISA. PFK-1 activity under optimal conditions at pH 8.0 was assayed; the regulatory properties of PFK-1 at pH 7.0 and total Proteins were also measured. The results showed a significant decrease (p<0.0001) in glucose, while cholesterol and triacylglycerol concentrations were a significant increase (p<0.0001) in insulin concentration and the enzyme activity in cinnamon treated groups. In conclusion, cinnamons have a scientific evidence to improve diabetes safely.

ASCI-ID: 38-1983

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