Protective Effect of Kombucha Tea on Liver Damage Induced by Thioacetamide in Rats

Research Article
Protective Effect of Kombucha Tea on Liver Damage Induced by Thioacetamide in Rats

Najmeh Kabiri, Mahboobeh Ahangar Darabi, Mahmoud Rafieian-Kopaei, Mahbubeh Setorki and Monir Doudi

Journal of Biological Sciences, 2014, 14(5), 343-348.

Abstract

The aim of this study is to evaluate the possible protective effects of Kombucha tea against thioacetamide induced liver damage in rats. A total of 24 male Wistar rats were divided into four groups: Control, treated with thioacetamide (TAA) treated with TAA and then Kombucha tea, treated with Kombucha tea and then TAA; following 3 weeks of treatment. All the animals were killed and liver tissue samples were obtained for histopathological investigation. The data showed that TAA significantly increased aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) but not bilirubin. The treatment by Kombucha tea promoted a significant reduction in serum enzyme levels AST, ALT, ALP, LDH and reduction in bilirubin content. The results show that the Kombucha tea has protective effects against the thioacetamide induced hepatotoxicity that might be due to antioxidant activities of these plants.

ASCI-ID: 38-2302

Cited References Fulltext

Similar Articles


Evaluation of Hepatoprotective Effects of Raphanas sativus L.

Journal of Biological Sciences, 2004, 4(4), 463-469.

Hepatoprotective Effect of the Aqueous Root-Bark Extract of Ficus sycomorus (Linn) on Carbon Tetrachloride Induced Hepatotoxicity in Rats

Journal of Biological Sciences, 2007, 7(2), 276-281.

Hydroalcoholic Extract of Terminalia arjuna:A Potential Hepatoprotective Herb

Journal of Biological Sciences, 2007, 7(2), 255-262.

The Effect of Pretreatment of Zerumbone on Fatty Liver Following Ethanol Induced Hepatotoxicity

Journal of Biological Sciences, 2008, 8(8), 1348-1351.

Antioxidant and Hepatoprotective Potential of Isolated Fraction of Revia hypocrateriformis

Journal of Biological Sciences, 2011, 11(6), 428-432.

Hepatoprotective Activity of Pineapple (Ananas comosus) Juice on Isoniazid-induced Rats

Journal of Biological Sciences, 2017, 17(8), 388-393.

Evaluation of Hepatoprotective, Antioxidant and Cytotoxic Properties of Isolated Flavonoids from Breynia disticha J.R.Forst. and G.Forst

Journal of Biological Sciences, 2018, 18(8), 475-487.

Rotenone-induced Parkinson`s Like Disease: Modulating Role of Coenzyme Q10

Journal of Biological Sciences, 2004, 4(4), 568-574.

Study on the Liver Functions in Rats Exposed to Benomyl

Journal of Biological Sciences, 2005, 5(5), 666-669.

Impact of Sildenafil Citrate (Viagra) with Ethanol Modulates on Lipid and Lipoprotein in Testis of Albino Rats

Journal of Biological Sciences, 2007, 7(2), 288-293.

Effects of Water Crude Leaf Extract of Sclerocarya birrea (A. Rich) Hochts (Anacardiaceae) on Normotensive Rat Blood Pressure

Journal of Biological Sciences, 2007, 7(3), 570-574.

The Effects of Clomiphene Citrate Administration in Ovariectomised Rats: An Ultrastructural Study

Journal of Biological Sciences, 2008, 8(1), 60-66.

Study of Oral Creatine Monohydrate Supplementation on Growth Performance and Histopathological Assessment in Rats and Chickens

Journal of Biological Sciences, 2008, 8(2), 436-440.

The Effects of Pre and Post Training Administration of MK-801 in Dorsal Hippocampus on Learning and Memory in Adult Male Rats

Journal of Biological Sciences, 2008, 8(2), 416-420.

The Ultrastructural and Stereological Study of Aqueous Extracts of Zataria multiflora Boiss and Elaeagnus angustifolia on the Mouse Fetus Stomach

Journal of Biological Sciences, 2007, 7(4), 648-652.

Impact of α-tocopherol on Metronidazole and Tetracycline-induced Alterations in Reproductive Activities of Male Albino Rats

Journal of Biological Sciences, 2007, 7(1), 41-46.

Genotoxicity and Molecular Changes of Hemoglobin Studies in Rats Exposed to 3 mT Static Magnetic Field

Journal of Biological Sciences, 2007, 7(7), 1121-1129.

Dose-dependent Effects of Iron Supplementation on Short-term and Long-term Memory in Adult Male Wistar Rats

Journal of Biological Sciences, 2010, 10(7), 648-652.

The Role of Opioid and α-adrenergic Receptors in the Ileal Antispasmodic Activity of Ruta chalepensis Extract

Journal of Biological Sciences, 2010, 10(8), 779-784.

Biochemical and Pathological Study of Protective Effect of Vitamin E in Azathioprine-Induced Hepatotoxicity in Rat

Journal of Biological Sciences, 2009, 9(4), 339-344.

A Comparison Study of Effects of Vitamin E and Silymarin on Phenytoin-Induced Cleft Palate in Rats

Journal of Biological Sciences, 2009, 9(4), 381-384.

Effect of Nanoparticles Fe4NiO4Zn on Liver Enzymes-White Blood Cell and Hematocrit in Wistar Rat

Journal of Biological Sciences, 2014, 14(7), 480-484.

The Role of β-Adrenoceptors at Inhibitory Effect of Hydroalcoholic Extract of Ruta chalepensis Leaf in Male Rat`s Ileum

Journal of Biological Sciences, 2008, 8(1), 88-94.

Aqueous Date Fruit Extract can’t Ameliorate β-amyloid Induced Memory Impairments in Male Rats

Journal of Biological Sciences, 2017, 17(2), 69-75.

Quercetin Does Not Alter Erythrocyte Osmotic Fragility in Female, Sprague Dawley Rats Fed a High-fructose, High-cholesterol Diet

Journal of Biological Sciences, 2019, 19(5), 347-353.

Inhibitory Effect of Melatonin on Histological Changes Induced in Rat Liver by Thioacetamide Intoxication

Journal of Biological Sciences, 2007, 7(1), 10-18.

Molecular Investigation of Gold Nanoparticles Toxicity in Mice Model and p53 Activation

Journal of Biological Sciences, 2019, 19(6), 391-395.

Cited By


Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences

Jundishapur Journal of Microbiology, 2015, 8(11), . DOI: 10.5812/jjm.25580

Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats

Saudi Journal of Biological Sciences, 2017, 24(4), 956. DOI: 10.1016/j.sjbs.2016.01.029

Effect of Luteolin and Quercetin on Thioacetamide Induced Hepatic Fibrosis in Rats

International Journal of Pharmacology, 2019, 15(7), 863. DOI: 10.3923/ijp.2019.863.871

Recent Evidence of the Beneficial Effects Associated with Glucuronic Acid Contained in Kombucha Beverages

Current Nutrition Reports, 2020, 9(3), 163. DOI: 10.1007/s13668-020-00312-6

Technological aspects of Kombucha, its applications and the symbiotic culture (SCOBY), and extraction of compounds of interest: A literature review

Trends in Food Science & Technology, 2021, (), . DOI: 10.1016/j.tifs.2021.02.017

Effect of kombucha intake on the gut microbiota and obesity-related comorbidities: A systematic review

Critical Reviews in Food Science and Nutrition, 2021, (), 1. DOI: 10.1080/10408398.2021.1995321

Recent advances in Kombucha tea: Microbial consortium, chemical parameters, health implications and biocellulose production

International Journal of Food Microbiology, 2022, 377(), 109783. DOI: 10.1016/j.ijfoodmicro.2022.109783

Test of Consolidation-Collapse Properties of the Black Soil of Northeast China Based on Burland Model

KSCE Journal of Civil Engineering, 2022, 26(8), 3235. DOI: 10.1007/s12205-022-0480-z

Towards an intelligent approaches for cotton diseases detection: A review

Computers and Electronics in Agriculture, 2022, 200(), 107255. DOI: 10.1016/j.compag.2022.107255

Awareness on abortion legality among undergraduate students in Nigerian Universities

Cogent Social Sciences, 2020, 6(1), . DOI: 10.1080/23311886.2020.1747334

Stochastic Multi-Objectives Supply Chain Optimization with Forecasting Partial Backordering Rate: A Novel Hybrid Method of Meta Goal Programming and Evolutionary Algorithms

Asia-Pacific Journal of Operational Research, 2017, 34(04), 1750021. DOI: 10.1142/S021759591750021X

Progress of artificial neural networks applications in hydrogen production

Chemical Engineering Research and Design, 2022, 182(), 66. DOI: 10.1016/j.cherd.2022.03.030