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Research Article
Aristolochia indica Whole Plant Extract as an Antineoplastic Agent

A. Y. K. M. Masud Rana and J. A. Khanam

Journal of Medical Sciences, 2002, 2(4), 202-205.

Abstract

The research work was conducted to determine the antitumor effect of Aristolochia indica (whole plant extract) against Ehrlich ascites carcinoma (EAC) in mice. Significant (P<0.001) increases of survival times (45±2 days) of the A. indica extract (50 mg kg-1) treated tumor bearing mice were confirmed with respect to the control group (23 ± 1.45 days). A. indica extract (50 mg kg-1) inhibited the tumor cell growth (94.12 %) and reversed the changes of hematological parameters consequent to tumor inoculation i.e. hemoglobin, 9.2±0.26 vs 7.5±0.3 gm dl-1; red blood cells, 7.1± 0.21 vs 2.44 ± 0.2 (cells ml-1)x109; white blood cells, 11 ± 0.17 vs 30 ± 0.49 (cells ml-1)x106; lymphocyte, 61.6 ± 1.3 vs 38.5 ± 2.1 %; neutrophil, 30 ± 3.08 vs 55.2±1.75 %; monocyte, 4.5 ± 0.5 vs 3.56 ± 0.47 %, for treated and control (EAC bearing) mice respectively.

ASCI-ID: 41-176

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