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Research Article
Blood Transfusion-mediated Viral Infections in Thalassemic Children in Bangladesh

Hossain Uddin Shekhar, Yearul Kabir, Mosharaf Hossain, Mesbah Uddin, Kaniz-Khatun- E-Jannat, Shahdat Hossain and Hussain Shahjalal

Journal of Medical Sciences, 2007, 7(1), 131-135.

Abstract

To assess the prevalence of transfusion-mediated viral infections in multi-transfused thalassemics in Bangladesh, forty-two thalassemic children (Male = 24, Female = 18) were recruited. All children were less than twelve years of age. Seromarkers for hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) were studied in these children prior to initiate blood transfusion and after they had received an average of 17.0±1.0 blood transfusions over a ten-month study period. The HBV and HCV markers were significantly higher in post-transfused subjects as compared to their pre-transfusion levels (HBsAg: 19.0 vs. 7.1%, p = 0.021 and anti-HCV: 16.7 vs. 2.4%, p<0.001). None of the thalassemic children was positive for HIV before or after transfusion. The serum total bilirubin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase levels also were significantly higher (p = 0.001, <0.001, <0.001 and <0.001, respectively) in post-transfused patients. Thus, HBV and HCV infections are major problems in multi-transfused thalassemic children in Bangladesh.

ASCI-ID: 41-555

Cited References Fulltext

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