Research Article
Crevicular Alkaline Phosphatase Activity During Orthodontic Tooth Movement: Canine Retraction Stage

A.A. A. Asma, M.A. W. Rohaya and Z.A. Shahrul Hisham

Journal of Medical Sciences, 2008, 8(3), 228-233.


To observe pattern of ALP activity in Gingival Crevicular Fluid (GCF) during canine retraction stage of fixed orthodontic treatment. Ten patients age between 15 to 27 years old with moderate upper labial segment crowding were recruited from postgraduate orthodontic clinic. The tested canines were distalized using nickel titanium push coil spring. The level of ALP at week 0 acted as the baseline. Samples were taken at day 0, at week 1, 4, 8 and 12. The activities of ALP were measured using spectrophotometer (405 nm). Paired sample t-test was used to assess the differences at weekly interval and between test and control groups over the study period. The ALP level was decreased in both the mesial and distal of the test teeth for the first month and stabilizes months after. Significant difference were detected from week 4 upward when compared to the baseline (p<0.05). The bony turnover specifically the bone formation can be monitored through the expression of ALP in the gingival crevicular fluid during orthodontic treatment.

ASCI-ID: 41-22

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