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Research Article
The Efficacy of Hypericum perforatum Extract on Recurrent Aphthous Ulcers

M. Motallebnejad, A. Moghadamnia and M. Talei

Journal of Medical Sciences, 2008, 8(1), 39-43.


According to anti-inflammatory and anti-nociceptive effects of Hypericum perforatum (St. John's wort), the aim of this study was to evaluate the efficacy of Hypericum perforatum extract on the management of Recurrent Aphthous Ulcers (RAU). Thirty patients with RAU participated in a randomly, placebo controlled double blind trial during three episodes of RAU to evaluate the efficacy of the topical hypericum containing mouthwash (0.5%). After a no-treatment run-in phase, patients were asked to use placebo mouthwash or hypericum mouthwash randomly. The diameters of ulcer and inflammatory halo (with 0.1 mm precision) and ulcer duration (day) were recorded and associated pain (Visual Analog Scale) were recorded by patients during each episode. Hypericum mouthwash resulted in a significant reduction of pain of RAU (p<0.05). Healing time was reduced in hypericum mouthwash group in comparison to other episodes (p = 0.052). Other indices did not show any significant differences. Hypericum perforatum extract in form of mouthwash (0.5%), may be of benefit in reduction of pain of RAU and has relative effect on reduction of healing time.

ASCI-ID: 41-18

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