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Research Article
Prevalence and Antibiotic Susceptibility Patterns of Bloodstream Salmonella Infections in a Tertiary Care Hospital, Dhaka

Hafsa Afroz, Md. Manjur Hossain, Md. Fakruddin, Md. Afzal Hossain, Zahed Uddin Mahmood Khan and Suvamoy Datta

Journal of Medical Sciences, 2013, 13(5), 360-366.

Abstract

Blood stream Salmonella infections range from self-limiting infections to life-threatening sepsis causing significant mortality and morbidity worldwide and require rapid and aggressive anti-microbial treatment. The antibiotic resistance pattern of Salmonella is ever changing over time. Rational and correct use of antibiotics requires understanding of the pathogen and drug resistance patterns in a community. This study was conducted to determine the status of bloodstream Salmonella infection and their antibiotic susceptibility patterns in a tertiary care hospital at Dhaka, Bangladesh. Six hundred and fifty six blood samples collected from clinically diagnosed enteric fever patients from Dhaka Medical college Hospital, Dhaka during January 2012 to December 2012 were processed. Salmonella enterica serovar typhi and paratyphi isolates were identified by standard microbiological and biochemical procedures. Ninty four isolates of Salmonella typhi and 59 isolates of S. paratyphi were isolated. Average prevalence rate of Salmonella in blood was 24.8%. Young, neonates and elderly persons are more prone to Salmonella infection and males are more susceptible to Salmonella septicemia than females. Most of the isolates Salmonella spp. were Multi-drug Resistance (MDR) and showed high resistance against cefixime, ceftriaxone, cefipime, ciprofloxacin, chloramphenicol and meropenem. Nalidixic acid was found to be effective against them. Specific antibiotic utilization strategies like antibiotic restriction, combination therapy and usage according to the standard antimicrobial susceptibility testing may help to decrease or prevent the emergence of resistance and incidence of blood stream infections.

ASCI-ID: 41-1187

Cited References Fulltext

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