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Research Article
Comparative Effects of Ficus exasperata Aqueous Leaf Extract and Furosemide on Urinary Excretion in DOCA-salt Hypertensive Rat

A.K. Amonkan, A.B. Konan, M.N. Bleyere, B.M.L. Ahui, L.K. Kouakou, G.M.K. Bouafou and S. Kati-Coulibaly

Journal of Medical Sciences, 2013, 13(5), 385-390.

Abstract

The prevalence of hypertension is increasing in many parts of the world. Management of this disease requires the use of diuretics, ACE inhibitors and β-blockers. In many pharmacopoeias, the leaves of Ficus exasperata are used to treat hypertension. The hypotensive effects of leaves of this species have been shown. The purpose of this study was to evaluate the diuretic effect of F. exasperata aqueous leaf extract (FEFIX) comparing to those of furosemide in salt hypertensive rats treated with deoxycorticosterone acetate (DOCA). Animals treated with DOCA were divided into three groups which received intraperitoneally NaCl (9‰, saline solution), FEFIX (100 mg kg-1 b.wt.) and furosemide (10 mg kg-1 b.wt.), respectively. Urine output was collected for 24 h. At the end of the experiment, the blood was collected and sampled. FEFIX and furosemide increased urinary volume (EUV) to 153.32±6.89 and 105.71±9.37%, respectively. F. exasperata aqueous leaf extract and furosemide increased the urinary excretion of electrolytes (Na+, Cl- and Ca2+), urea and creatinine. However, excretions induced by the plant extract were greater than those induced by furosemide. FEFIX and furosemide decreased the rate of plasma electrolytes with a decrease in serum sodium greater for this extract. The studied extract decreased urea and plasma creatinine like furosemide. These results showed that the diuretic effects of F. exasperata aqueous leaf extract were similar to those of furosemide in hypertension due to salt overload. However, the diuretic effects of this plant extract were superior to those of furosemide.

ASCI-ID: 41-1184

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