Relationship between Angiotensinogen gene T174M Polymorphism and Essential
Hypertension in a Sample of Algerian Population: Case Control Study
F. Mesli Taleb Bendieb
M.B. Baba Hamed
Journal of Medical Sciences,
2014, 14(4), 168-173.
Essential hypertension is a multifactorial complex trait. It affects around one billion people worldwide. Many genes have been incriminated in its onset. This study aimed to determine the association of the AGT T174M gene variant with essential hypertension in a sample of Algerian population of the Oran city. In this study, we involved 350 subjects, 180 hypertensives and 170 normotensives. Consents were obtained from all the participated subjects. Polymerase Chain Reaction (PCR) combined with Restrictive Fragment Length Polymorphism (RFLP) was used to detect the T174M variant of angiotensinogen (AGT) gene. Blood pressure, body height and weight, fasting blood glucose and serum lipid were measured in all subjects. The genotypic and allelic distribution of the T174M variant of the AGT gene did not differ in hypertensives and normotensives group (OR = 1.05; 95% CI [0.583-1.932]; χ2 = 5.298; p>0.05; χ2 = 5.692; p>0.05), where the frequency of genotypes in the patient with essential hypertension was TT: 64.4%; TM: 20.5%; MM: 15% vs. TT: 55.8%; TM: 19.4%; MM: 24.7% for the controls. The allelic frequency was 0.7 vs. 0.66 for the T allele and 0.26 vs. 0.34 for the mutant allele in hypertensives and controls, respectively. This study shows that the T174M variant of the AGT gene is not associated with essential hypertension in this sample of Algerian population of the Oran city.
Cited References Fulltext
The genes polymorphism of angiotensinogen (AGT) M235T and AGT
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