Research Article 
Anti-Diabetic Property and Phytochemical Composition of Aqueous and Methanol Extracts of Buchholzia coriacea Seeds in Alloxan-Induced Diabetic Rats
I.K. Obiudu, A.C. Okolie, K.N. Agbafor, M.E. Unaegbu, G.A. Engwa and C.V. Obiudu
Journal of Medical Sciences, 2015, 15(5), 241-245.
Abstract
The present study was aimed at investigating the anti-diabetic properties and photochemical constituents of aqueous and methanol extracts of Buchholzia coriacea seeds in albino rats. Phytochemical screening was performed using standard procedures. Forty five adult male albino rats, placed in nine groups (A-I), of five in each group were used. Diabetes was induced intraperitoneally with a single dose of 100 mg kg–1 b.wt., of alloxan monohydrate solution. After diabetes induction (in all the groups except I), groups A, B and C were orally administered 100, 200 and 400 mg kg–1 b.wt., of aqueous extract respectively, D, E and F received 100, 200 and 400 mg kg–1 b.wt., of methanol extract respectively, while G was given glibenclamide (antidiabetic drug) 2 mg kg–1 b.wt., Groups H and I received distilled water only. Administration was done twice daily for fourteen days. Phytochemical screening of the extracts revealed the presence of alkaloids, flavonoids, tannins, saponins, anthraquinones and glycosides. The glucose concentration of all the groups treated with alloxan monohydrate was significantly higher (p<0.05) than the untreated one. After treatment with the extract and the drug (Glibenclamide), there was a significant reduction (p<0.05) in glucose concentration of the administered groups relative to the untreated. The effect was linearly dose-dependent. The difference between the groups given the extracts and the one treated with glibenclamide was significant (p<0.05). The effect of the aqueous extracts was not significantly different (p>0.05) from that of methanol extract. The result of this research indicates that aqueous and methanol extracts of Buchholzia coriacea seeds possess the ability to reduce blood glucose level and may be partly responsible for its application in treatment of diabetes.
ASCI-ID: 41-1311
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