Research Article
Ameliorative Effects of Extract of Carica papaya Leaf and Metformin on Streptozotocin-Induced Diabetic Rats

A.J. Ajibade and E.O. Orekoya

Journal of Medical Sciences, 2022, 22(4), 170-177.

Abstract

Background and Objective: Carica papaya Linn has been used for the management of several ailments in African and Asian ethnomedicine. This study investigated the effects of aqueous extract of Carica papaya leaves and metformin on the pancreas of streptozotocin (STZ) induced diabetic Wistar rats. Materials and Methods: Forty-five Wistar rats consisting of Group A regarded as control while diabetes was induced in Group B, C, D and E with intraperitoneal administration of 60 mg kg1 STZ. Group B served as diabetic control while Group C and D were treated with 1.0 g/100 mL and 3.0 g/100 mL of the extract administered as drinking water daily for six weeks, respectively. Group E was treated with 5000 mg kg1 of metformin and animals were sacrificed processed for histological analysis. Results: The result of aqueous extract of Carica papaya leaf and metformin-treated rats showed a significant reduction in fasting blood sugar levels (FBS) in Group D and E (p<0.05) compared to Group A control and B diabetic group. Treatment with metformin and aqueous extract significantly decreased (p<0.05) the levels of serum biomarkers Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and Alkaline Phosphatase (ALP) in the diabetic treated groups compared to diabetic group. Administration of aqueous extract of Carica papaya leaves and metformin preserved the morphological architecture of the pancreas in Group D and E when compared to the diabetic group. Conclusion: This study concluded that aqueous extract of Carica papaya leaves and metformin ameliorated effects of STZ induced diabetes which improved metabolic disruptions and imbalances caused by diabetes in Wistar rats.

ASCI-ID: 41-1430

Cited References Fulltext

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