Search. Read. Cite.

Easy to search. Easy to read. Easy to cite with credible sources.

Research Article
Neuropsychobehavioral Effects and Anticancer Activity of Some Substituted Triazolo[4,3-a][1,4]Benzodiazepines

K.K. Vijaya Raj, B. Narayana, N. Suchetha Kumari, B.V.Ashalatha and B.K. Sarojini

Journal of Pharmacology and Toxicology, 2006, 1(5), 471-477.


Neuropsychobehavioral effects and anticancer screening of some 8-chloro-6-(2-fluorophenyl)-1-(aryl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines (3a-f) are discussed. The compounds were evaluated for antianxiety properties, effects on coordination and effects on learning and memory. The compounds were also screened for their anticancer activity. All the compounds possessed variable antianxiety properties and three of them possessed skeletal muscle relaxant property. One of the compound exhibited promising anticancer activity.

ASCI-ID: 55-62

Cited References Fulltext

Cited By

An straightforward entry to new pyrazolo-fused dibenzo[1,4]diazepines

Organic & Biomolecular Chemistry, 2011, 9(7), 2251. DOI: 10.1039/c0ob00812e

Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives

Molecules, 2012, 17(8), 8762. DOI: 10.3390/molecules17088762