Research Article 
Anti-Inflammatory Activity of Extracts from Parkia biglobosa (Jacq.) R.Br. Ex G.Don. (Fabaceae-Mimosoideae) Trunk Bark
Noufou Ouedraogo, Constantin Atchade, Tata Kadiatou Traore, Benjamin Ouedraogo, Boly A.G. Laurent, W.L.M. Esther Kabre, Jules Yoda, Felix B. Kini, Marius Lompo, Moussa Ouedraogo and Sylvin Ouedraogo
Journal of Pharmacology and Toxicology, 2021, 16(1), 1-8.
Abstract
Background and Objective: Parkia biglobosa is used in the treatment of several inflammatory pathologies. The work aimed to study the toxicity, anti-inflammatory, analgesic and antioxidant effects of aqueous and hydroethanolic extracts from the bark of the trunk of Parkia biglobosa. Materials and Methods: A phytochemical study was carried out using the TLC method and the toxicity of the extracts was evaluated. The anti-inflammatory effect of extracts was evaluated using mice paw edema-induced by carrageenan injection and ear edema by croton oil application and these inhibitor effects against LOX and COX. The analgesic effect of the extracts was evaluated according to the writhing test. DPPH, FRAP, ABTS and LPO methods were used to evaluate antioxidant capacity. Results: Aqueous and hydroethanolic extracts are considered as slightly toxic substances. Extracts significantly reduced edema caused by carrageenan. At a dose of 500 μg/ear, the extracts used reduced (more than 50%) the edema caused by the application of croton oil to the inner surface of the ear of mice. Both extracts inhibited pro-inflammatory enzymes (LOX, COX 1 and 2) activities. Extracts exhibited antioxidant power using four methods (DPPH, FRAP, ABTS and LPO). Conclusion: These results are scientific data that could therefore justify the use of Parkia biglobosa trunk bark in the treatment of inflammatory diseases in traditional medicine.
ASCI-ID: 55-503
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