Research Article
Combination of an Antiviral Drug and Immunomodulation against Hepadnaviral Infection in the Woodchuck Model

Mengji Lu, Xin Yao, Yang Xu, Heike Lorenz, Uta Dahmen, Haidong Chi, Olaf Dirsch, Thekla Kemper, Lifang He, Dieter Glebe, Wolfram H. Gerlich, Yumei Wen and Michael Roggendorf

Journal of Virology, 2008, 82(5), 2598-2603. DOI: 10.1128/JVI.01613-07

Abstract

The essential role of multispecific immune responses for the control of hepatitis B virus (HBV) infection implies the need of multimodal therapeutic strategies for chronic HBV infection, including antiviral chemotherapy and immunomodulation. This hypothesis was tested in the woodchuck model by a combination of lamivudine pretreatment and subsequent immunizations of woodchucks chronically infected with woodchuck hepatitis virus. The immunizations were performed with DNA vaccines or antigen-antibody immune complexes (IC)/DNA vaccines. Immunizations with IC/DNA vaccines led to an anti-woodchuck hepatitis virus surface antibody response and significant reductions of viral load and antigenemia, suggesting that such a strategy may be effective against chronic HBV infection.

ASCI-ID: 205-243

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