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Research Article
Quantitative Examination of Aerobic Bacteria and Fungi in Locally Available Antacid Suspension and Possible Contamination by Specified Bacteria

Mahboob Hossain, Shamim Ara and Mohammed Zakiur Rahman

Pakistan Journal of Biological Sciences, 2004, 7(11), 2014-2017.


The microbiological status of liquid antacid suspension of 20 pharmaceutical industries of Bangladesh were studied. Aerobic viable microbial count of 27 (75%) out of 36 samples studied were found to exceed the USP limit. Viable microbial count varied between less than 102 CFU mL-1 and greater than 106 CFU mL-1. In 11 (30%) samples of 8 companies the total aerobic microbial count was more than 103 CFU mL-1. Microbial counts of two large reputed pharmaceutical companies were 1000 fold higher than those of some small companies. None of the samples contained Escherichia coli and Salmonella spp. Out of 36 samples 1 (2.5%) of the 2 samples of one company having different manufacturing date contained Pseudomonas aeruginosa and both samples (5%) having different manufacturing date of another large company contained Staphylococcus aureus. No significant correlation between pH deviation and contamination by microbes was observed.

ASCI-ID: 1-3360

Cited References Fulltext

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