Research Article 
Toxicity Effect of Zinc Supplementation on the Liver Tissue
M.E Guldur, M. Ozaslan, T. Aytekin, I.H. Kilic and I.D. Afacan
Pakistan Journal of Biological Sciences, 2006, 9(6), 1139-1142.
Abstract
The ability of zinc to retard oxidants and to be antioxidant has been recognized for many years. In the present study, it is aimed to determine histological toxic effects of zinc supplementation on hepatic tissue. It was also planned to determine effect of zinc on TAL. In this study, 24 male Wistar albino rats were used. All animals were divided 4 groups; 1 control, 3 experimental group. Three milliliter (227 mg L-1 day-1) zinc-sulphate was treated in experimental groups during 15, 30 and 45 days, respectively. TAL, AST and ALT levels from collected cardiac blood samples (3 mL) were measured. For histological investigation, liver tissue was removed and stained with Haematoxilen-eosin. It was determined that, TAL reduced in group I which was given zinc during 15 days and TAL increased in group II and Group III which was given zinc 30 and 45 days, respectively compared to that of group control. Results of the histological investigation showed that no toxicity in even experimental groups.
ASCI-ID: 1-3998
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