Research Article 
Prevalence of Dyslipidemic Phenotypes Including Hyper-apoB and Evaluation of Cardiovascular Disease Risk in Normocholesterolemic Type 2 Diabetic Patients
Hossain Uddin Shekhar, Hussain Md. Shahjalal, Rumana Ahmed, Mesbah Uddin and Kaniz-Khatun-E-Jannath
Pakistan Journal of Biological Sciences, 2006, 9(8), 1536-1541.
Abstract
Diabetic patients are vulnerable to different lethal diseases including cardiovascular disease, which is still ranked as the number one killer disease in the world. In the present study, the vulnerability of diabetic patients to cardiovascular disease was evaluated considering apoB level as a predictor. Randomly selected Bangladeshi 96 type 2 diabetic patients (M = 48, F = 48) and 49 healthy non-diabetic individuals (M = 37, F = 12) were recruited to compare their anthropometric and biochemical features. Among the diabetic subjects 32 were hypercholesterolemic (LDL-C>150 mg dL-1) and 64 were normocholesterolemic (LDL-C<150 mg dL-1). The biochemical parameters compared were total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein B (apoB). The values for the diabetic patients vs. control were: TC, 214±46 vs. 186±18 mg dL-1; LDL-C, 143±40 vs. 120±18 mg dL-1; TG, 192±79 vs.141±33 mg dL-1 and HDL-C, 35±6 vs. 39±7 mg dL-1; with all p value<0.05. The values for the normocholesterolemic diabetic patients vs. control were: TC, 189±28 vs.186±18 mg dL-1; LDL-C, 120±23 vs. 120±18 mg dL-1; TG, 184±84 vs. 141±33 mg dL-1 and HDL-C, 35±7 vs. 39±7 mg dL-1; of which values of TG and HDL-C were significant. Serum apoB level for the diabetic patients vs. control was 1.15±0.28 vs. 0.926±0.25 g L-1 (p<0.05) and the normocholesterolemic diabetic patients vs. control was 1.06±0.26 vs. 0.926±0.25 g L-1 (p<0.05). 47% (n = 30) of the normocholesterolemic diabetic patients had hyper-apoB, of which 22% were hypertriglyceridemic and 25% were normotriglyceridemic. Surprisingly, hyper-apoB was also found in 14% of control. Thus apoB identified the high-risk phenotypes in normocholesterolemic diabetic patients and it should be used to evaluate the lipidic pattern of these patients.
ASCI-ID: 1-4068
Related Articles
Effects of Germinated Seeds of Trigonella foenum graecum (Fenugreek) and Cholestyramine on Blood Lipids Profile and Aortic Fatty Streak in Rabbit
Pakistan Journal of Biological Sciences, 2005, 8(11), 1529-1532.
Comparison of Risk Factors of CHD in the Men and Women with MIPakistan Journal of Biological Sciences, 2010, 13(7), 344-347.
The Hypolipidemic Effect of Citrullus colocynthis on Patients with HyperlipidemiaPakistan Journal of Biological Sciences, 2010, 13(24), 1202-1207.
Lipidemic Responses of Male Broiler Chickens to Enzyme-supplemented Wheat-soybean Meal-based Diets with Various Levels of Metabolizable EnergyPakistan Journal of Biological Sciences, 2013, 16(21), 1295-1302.
Effect of Acacia nilotica Fruit Extract on Serum Glucose and Lipid Concentrations in Alloxan-induced Diabetic RatsPakistan Journal of Biological Sciences, 2013, 16(21), 1398-1402.
Effect of Ambrex (A Herbal Formulation) on Hematological Variables in Hyperlipidemic RatsPakistan Journal of Biological Sciences, 2014, 17(5), 740-743.
Purslane and Garden Cress Seeds as Source of Unconventional Edible Oils for Prevention of HyperlipidemiaPakistan Journal of Biological Sciences, 2019, 22(11), 537-544.
Prevalence of Metabolic Syndrome in Type 2 Diabetics and its Relation with Neck CircumferencePakistan Journal of Biological Sciences, 2020, 23(6), 719-725.
Prevalence of Abnormal Serum Alanine Aminotransferase Levels in Type 2 Diabetic Patients in IranPakistan Journal of Biological Sciences, 2008, 11(18), 2274-2277.
The Effect of Hydro Alcoholic Nettle (Urtica dioica) Extract on Oxidative Stress in Patients with Type 2 Diabetes: A Randomized Double-blind Clinical TrialPakistan Journal of Biological Sciences, 2012, 15(2), 98-102.
Prevalence of Metabolic Syndrome in Type 2 Diabetics and its Relation with Neck CircumferencePakistan Journal of Biological Sciences, 2020, 23(6), 719-725.
Prevalence and Impact of Weight Self Stigmatization on Type II Diabetes Glycemic and Cardiovascular Markers ControlPakistan Journal of Biological Sciences, 2020, 23(10), 1285-1290.
Impact of Gender on Type II Diabetes Glycemic and Cardiovascular Markers Control and TreatmentPakistan Journal of Biological Sciences, 2020, 23(12), 1643-1649.
Cited By
Comparison of Risk Factors of CHD in the Men and Women with MI
Pakistan Journal of Biological Sciences, 2010, 13(7), 344. DOI: 10.3923/pjbs.2010.344.347
The Effect of Hydroalcholic Nettle (Urtica dioica) Extracts on Some Cardiovascular Risk Factors in Patients With Type 2 DiabetesJournal of Medical Sciences(Faisalabad), 2011, 11(3), 138. DOI: 10.3923/jms.2011.138.144