Search. Read. Cite.

Easy to search. Easy to read. Easy to cite with credible sources.

Research Article
Estrogen and Progesterone Receptor Status in Tumor Samples of Iranian Breast Cancer Patients

M Hashemi and F. Karami-Tehrani

Pakistan Journal of Biological Sciences, 2006, 9(5), 854-858.

Abstract

Breast cancer is the most common neoplasm affecting women in the western world where the incidence is very high and the risk of developing breast cancer is 1 out of 10. The incidence of breast cancer in Iran is much lower; although it is the most common cancer among Iranian women (skin cancer is excluded). For optimum management of these patients, assay of certain biochemical markers is necessary. Breast Carcinomas that express Estrogen Receptor (ER) and Progesterone Receptor (PR) are more likely to benefit from adjuvant hormonal therapy and have a better prognosis, stage for stage, than those with receptor-negative tumors. Clinically; the most useful markers in breast cancer are estrogen and progesterone receptors that are used to predict response to hormone therapy. In the present study the levels of Estrogen Receptor (ER) and progesterone receptor (PgR) were determined in 48 specimens of primary breast cancers using gold standard biochemical assay of steroid hormone receptors by the Dextran-coated Charcoal method (DCC). The commonest histological type of breast tumor was infiltrating ductal carcinoma that accounts for the 81.5 percent of breast cancers. The results demonstrated that 39.6% were ER+, PgR+; 22.9% ER+, PgR-; 31.3% ER-, PgR- and 6.3% ER-,PgR+. In postmenopausal, the incidence of estrogen receptor positive tumors (ER+) was significantly higher than premenopausal (p<0.05). Although the frequency of progesterone receptor positive (PgR+) breast tumors is higher in postmenopausal than premenopausal but the difference is not significance (p>0.05).

ASCI-ID: 1-3950

Cited References Fulltext

Related Articles


Serum Lipid Profile of Breast Cancer Patients

Pakistan Journal of Biological Sciences, 2009, 12(4), 332-338.

Comparison the Effects of Two Educational Methods on Knowledge, Attitude and Practices of Arak Physicians about Breast Cancer

Pakistan Journal of Biological Sciences, 2010, 13(18), 901-905.

Paclitaxel Loaded Niosome Nanoparticle Formulation Prepared via Reverse Phase Evaporation Method: An in vitro Evaluation

Pakistan Journal of Biological Sciences, 2013, 16(6), 295-298.

Is Macromastia a Risk Factor for Breast Cancer? A Study on 198 Patients

Pakistan Journal of Biological Sciences, 2013, 16(21), 1348-1352.

Anti-proliferation and Apoptosis Induction of Aqueous Leaf Extract of Carica papaya L. on Human Breast Cancer Cells MCF-7

Pakistan Journal of Biological Sciences, 2017, 20(1), 36-41.

Evaluation of MiR-21 and MiR-10b Expression of Human Breast Cancer in West Sumatera

Pakistan Journal of Biological Sciences, 2017, 20(4), 189-196.

Active Compounds from Curcuma longa and Comparison of their Effectively Induced Apoptosis in MCF-7 Cell

Pakistan Journal of Biological Sciences, 2021, 24(1), 35-41.

Role of Human PTEN and TP53 Sequence Mutations in the Etiology of Breast Cancer in Saudi Patients

Pakistan Journal of Biological Sciences, 2020, 23(3), 321-330.

Evaluation of Angiogenesis by Using CD105 and CD34 in Sudanese Breast Cancer Patients

Pakistan Journal of Biological Sciences, 2021, 24(11), 1144-1151.

Effects of Oncogene Neuregulin 1 on Breast Cancer Cells

Pakistan Journal of Biological Sciences, 2022, 25(4), 345-352.

Status of Ki-67, Estrogen and Progesterone Receptors in Various Subtypes of Intracranial Meningiomas

Pakistan Journal of Biological Sciences, 2012, 15(11), 530-535.

Therapeutic Efficacy of Melatonin Against Polycystic Ovary Syndrome (PCOS) Induced by Letrozole in Wistar Rat

Pakistan Journal of Biological Sciences, 2018, 21(7), 340-347.

Progesterone Receptor Positive Colorectal Tumors Have Lower Thymidine Phosphorylase Expression: An Immunohistochemical Study

Pakistan Journal of Biological Sciences, 2007, 10(24), 4485-4489.

Status of Ki-67, Estrogen and Progesterone Receptors in Various Subtypes of Intracranial Meningiomas

Pakistan Journal of Biological Sciences, 2012, 15(11), 530-535.

Cited By


Expression of Epidermal Growth Factor Receptor Tyrosine Kinase Family in Fine Needle Aspiration and Permanent Specimens of Invasive Lobular and Ductal Breast Cancers

Pakistan Journal of Biological Sciences, 2011, 14(10), 584. DOI: 10.3923/pjbs.2011.584.589